Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks. - Wikidata - wikimedia - TriplyDB

Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.

Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.

http://www.wikidata.org/entity/Q39793584

about

Small molecule inhibitors of zinc-dependent histone deacetylases Effects of different tissue microenvironments on gene expression in breast cancer cells Initial steps of metastasis: cell invasion and endothelial transmigration Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells Current approaches to the treatment of metastatic brain tumours.Translational research in brain metastasis is identifying molecular pathways that may lead to the development of new therapeutic strategies.DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer.Profound prevention of experimental brain metastases of breast cancer by temozolomide in an MGMT-dependent manner.Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer.Manipulating protein acetylation in breast cancer: a promising approach in combination with hormonal therapies?Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In Vivo Metastasis Model.Validating the use of a luciferase labeled breast cancer cell line, MDA435LCC6, as a means to monitor tumor progression and to assess the therapeutic activity of an established anticancer drug, docetaxel (Dt) alone or in combination with the ILK inh Triple-negative breast cancer: new perspectives for targeted therapies.Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo.Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer.Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.HIV-1 target cells in the CNS.In vivo bioluminescence imaging of tumor hypoxia dynamics of breast cancer brain metastasis in a mouse model.Opposing effects of pigment epithelium-derived factor on breast cancer cell versus neuronal survival: implication for brain metastasis and metastasis-induced brain damage.The biology of brain metastases-translation to new therapies Mouse models of advanced spontaneous metastasis for experimental therapeutics.Preclinical approaches to study the biology and treatment of brain metastases.Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases.In Vivo Magnetic Resonance Imaging for Investigating the Development and Distribution of Experimental Brain Metastases due to Breast Cancer Targeting triple-negative breast cancer cells with the histone deacetylase inhibitor panobinostat.Histone deacetylase inhibitor-mediated cell death is distinct from its global effect on chromatin.Penfluridol: An Antipsychotic Agent Suppresses Metastatic Tumor Growth in Triple-Negative Breast Cancer by Inhibiting Integrin Signaling Axis.Breast cancer brain metastases: new directions in systemic therapy Pazopanib inhibits the activation of PDGFRβ-expressing astrocytes in the brain metastatic microenvironment of breast cancer cells Epigenetic alterations by NuRD and PRC2 in the neonatal mouse cochlea Breast cancer metastasis: issues for the personalization of its prevention and treatment.Suberoylanilide hydroxamic acid represses glioma stem-like cells.Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.Roadblocks to translational advances on metastasis research.A novel histone deacetylase inhibitor, CKD5, has potent anti-cancer effects in glioblastoma.Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases.Brain metastases as preventive and therapeutic targets.Rethinking the metastatic cascade as a therapeutic target.HDAC inhibitors in HIV.

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Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.

http://www.wikidata.org/entity/Q39793584

description

2009 nî lūn-bûn

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2009年の論文

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2009年论文

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2009年论文

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name

Vorinostat inhibits brain meta ...... uces DNA double-strand breaks.

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Vorinostat inhibits brain meta ...... uces DNA double-strand breaks.

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type

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Vorinostat inhibits brain meta ...... uces DNA double-strand breaks.

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Vorinostat inhibits brain meta ...... uces DNA double-strand breaks.

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Vorinostat inhibits brain meta ...... uces DNA double-strand breaks.

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Vorinostat inhibits brain meta ...... uces DNA double-strand breaks.

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Clinical Cancer Research

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Vorinostat inhibits brain meta ...... uces DNA double-strand breaks.

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David J Liewehr

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Diane Palmieri

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Eleazar Vega-Valle

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Elizabeth Hargrave

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Emily Hua

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Fancy C Thomas

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Helen R Thorsheim

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Jeanne Herring

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John F Reilly

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Julie A Gaasch

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scholarly article

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10.1158/1078-0432.CCR-09-1039

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