A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation - Wikidata - wikimedia - TriplyDB

A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

http://www.wikidata.org/entity/Q39793982

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Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling The Ikaros family of zinc-finger proteins RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence FOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development.Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia.Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia.Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation.Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate.Integrated signaling in developing lymphocytes: the role of DNA damage responses.The Transcription Factor Bach2 Is Phosphorylated at Multiple Sites in Murine B Cells but a Single Site Prevents Its Nuclear Localization.RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals.RETRACTED: The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination.Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells Survival factor NFIL3 restricts FOXO-induced gene expression in cancer Lymphocyte development: integration of DNA damage response signaling.B cell lymphoma in HIV transgenic mice.Prolactin levels correlate with abnormal B cell maturation in MRL and MRL/lpr mouse models of systemic lupus erythematosus-like disease CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis.Balancing Proliferation with Igκ Recombination during B-lymphopoiesis Toll-like receptor 4-mediated signaling regulates IL-7-driven proliferation and differentiation of B-cell precursors.Transcriptional control of early T and B cell developmental choices The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia.Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia.Assembly and Function of the Precursor B-Cell Receptor.The miR-15 family reinforces the transition from proliferation to differentiation in pre-B cells.Total cellular protein presence of the transcription factor IRF8 does not necessarily correlate with its nuclear presence.Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3.Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation MK5 activates Rag transcription via Foxo1 in developing B cells.SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas Cell cycle RNA regulons coordinating early lymphocyte development.Mechanisms of central tolerance for B cells.A Chemoattractant-Guided Walk Through Lymphopoiesis: From Hematopoietic Stem Cells to Mature B Lymphocytes.The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling.PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development Dual Mechanism of Rag Gene Repression by c-Myb during Pre-B Cell Proliferation.The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes.Metabolic gatekeeper function of B-lymphoid transcription factors Human pre-B cell receptor signal transduction: evidence for distinct roles of PI3kinase and MAP-kinase signalling pathways.

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A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

http://www.wikidata.org/entity/Q39793982

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name

A self-reinforcing regulatory ...... signaling and differentiation

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A self-reinforcing regulatory ...... signaling and differentiation

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A self-reinforcing regulatory ...... signaling and differentiation

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Aaron R Dinner

http://www.w3.org/2001/XMLSchema#string

Eric Bertolino

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Harinder Singh

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Joseph R Triggs

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Kyoko Ochiai

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Malay Mandal

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Marcus R Clark

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Mark Maienschein-Cline

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Roger Sciammas

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P2860

PKC eta directs induction of IRF-4 expression and Ig kappa gene rearrangement in pre-BCR signaling pathway

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.

BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo

Foxp1 is an essential transcriptional regulator of B cell development

Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate.

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300-307

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10.1038/NI.2210

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3

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13

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2012-01-22T00:00:00Z

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221768291

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22267219

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4028049

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