Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation.
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Regulation of G protein-coupled receptors by allosteric ligandsThe Role of Muscarinic Receptors in the Pathophysiology of Mood Disorders: A Potential Novel Treatment?14-3-3 Proteins Buffer Intracellular Calcium Sensing Receptors to Constrain SignalingMolecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor InternalisationAllosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's diseaseAllosteric Modulation of Muscarinic Acetylcholine Receptors.All muscarinic acetylcholine receptors (M1-M5) are expressed in murine brain microvascular endothelium.Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activationNovel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal modelsDistinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1).Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficitsOrthosteric- and allosteric-induced ligand-directed trafficking at GPCRs.Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulationDisease-Modifying Effects of M1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer's Disease Mouse Model.
P2860
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P2860
Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Contrasting effects of alloste ...... alization and down-regulation.
@en
Contrasting effects of alloste ...... alization and down-regulation.
@nl
type
label
Contrasting effects of alloste ...... alization and down-regulation.
@en
Contrasting effects of alloste ...... alization and down-regulation.
@nl
prefLabel
Contrasting effects of alloste ...... alization and down-regulation.
@en
Contrasting effects of alloste ...... alization and down-regulation.
@nl
P2093
P2860
P356
P1476
Contrasting effects of alloste ...... alization and down-regulation.
@en
P2093
Christopher J Langmead
Martyn D Wood
R A John Challiss
Rachel L Thomas
P2860
P304
P356
10.1124/JPET.109.160242
P407
P577
2009-09-18T00:00:00Z