Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway.
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Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21Improved significance test for DNA microarray data: temporal effects of shear stress on endothelial genes.Early changes in lung gene expression due to high tidal volume.Live in vivo imaging of Egr-1 promoter activity during neonatal development, liver regeneration and wound healingMechanical stress and human aortic smooth muscle cell proliferationSuppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1.The impact of molecular medicine upon early cardiovascular drug development.Egr-1 expression during neointimal development in flow-associated pulmonary hypertension.Angioadaptation: keeping the vascular system in shape.The transcription factor Egr-1: a potential drug in wound healing and tissue repair.Molecular control of capillary growth in skeletal muscle.Induction of the early growth response 1 gene by Epstein-Barr virus lytic transactivator Zta.Mechanical stress is communicated between different cell types to elicit matrix remodelingEvidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function.Investigation of biomimetic shear stress on cellular uptake and mechanism of polystyrene nanoparticles in various cancer cell lines.Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?Quantifying cardiovascular flow dynamics during early development.Mechanoregulation of gene expression in fibroblasts.Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum.Gene regulation by mechanotransduction in fibroblasts.Differential effects of shear stress and cyclic strain on Sp1 phosphorylation by protein kinase Czeta modulates membrane type 1-matrix metalloproteinase in endothelial cells.Systematic review of molecular mechanism of action of negative-pressure wound therapy.Endothelial exposure to hypoxia induces Egr-1 expression involving PKCalpha-mediated Ras/Raf-1/ERK1/2 pathway.Sequential activation of protein kinase C (PKC)-alpha and PKC-epsilon contributes to sustained Raf/ERK1/2 activation in endothelial cells under mechanical strain.Tendon development and diseases.A cell-based sensor of fluid shear stress for microfluidics.Proximal cyclic AMP response element is essential for exendin-4 induction of rat EGR-1 gene.Zinc finger transcription factor Egr-1 is involved in stimulation of NHE2 gene expression by phorbol 12-myristate 13-acetate.Angiotensin II-induced transcriptional activation of the cyclin D1 gene is mediated by Egr-1 in CHO-AT(1A) cells.Oscillating fluid flow inhibits TNF-alpha -induced NF-kappa B activation via an Ikappa B kinase pathway in osteoblast-like UMR106 cells.Transcription upregulation via force-induced direct stretching of chromatin.Transcriptional stimulation of the human NHE3 promoter activity by PMA: PKC independence and involvement of the transcription factor EGR-1.Mechanisms of estrogen receptor action in the myocardium. Rapid gene activation via the ERK1/2 pathway and serum response elements.Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling.Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress.Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro.Transcription factor Sp1 phosphorylation induced by shear stress inhibits membrane type 1-matrix metalloproteinase expression in endothelium.Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2.Suppression of early growth response factor-1 with egr-1 antisense oligodeoxynucleotide aggravates experimental duodenal ulcers.Egr-1 regulates RTA transcription through a cooperative involvement of transcriptional regulators.
P2860
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P2860
Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Fluid shear stress activation ...... ivated protein kinase pathway.
@en
Fluid shear stress activation ...... ivated protein kinase pathway.
@nl
type
label
Fluid shear stress activation ...... ivated protein kinase pathway.
@en
Fluid shear stress activation ...... ivated protein kinase pathway.
@nl
prefLabel
Fluid shear stress activation ...... ivated protein kinase pathway.
@en
Fluid shear stress activation ...... ivated protein kinase pathway.
@nl
P2093
P2860
P356
P1476
Fluid shear stress activation ...... ivated protein kinase pathway.
@en
P2093
C Campbell
J L Schwachtgen
M Braddock
V Sukhatme
P2860
P304
P356
10.1172/JCI1404
P407
P577
1998-06-01T00:00:00Z