Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors. - Wikidata - wikimedia - TriplyDB

Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.

Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.

http://www.wikidata.org/entity/Q39808264

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GIST-T1 GIST48 GIST48B GIST522 GIST62 GIST882 LMS03 LPS141 RMS176

P1343

Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90 Pharmacological treatment options for mast cell activation disease Emerging Agents for the Treatment of Advanced, Imatinib-Resistant Gastrointestinal Stromal Tumors: Current Status and Future Directions p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors Phase I study of panobinostat and imatinib in patients with treatment-refractory metastatic gastrointestinal stromal tumors New therapeutic targets in soft tissue sarcoma.Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways.Inhibition of KIT-glycosylation by 2-deoxyglucose abrogates KIT-signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor.SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis.Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma.Anti-tumor effects of the Notch pathway in gastrointestinal stromal tumors Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat.Update on imatinib for gastrointestinal stromal tumors: duration of treatment.Gastrointestinal stromal tumors: management of metastatic disease and emerging therapies.Inhibitor of Apoptosis Proteins (IAPs) are commonly dysregulated in GIST and can be pharmacologically targeted to enhance the pro-apoptotic activity of imatinib Vorinostat in combination with bortezomib in patients with advanced malignancies directly alters transcription of target genes.Histone deacetylase inhibitor SAHA mediates mast cell death and epigenetic silencing of constitutively active D816V KIT in systemic mastocytosis.Molecular basis for primary and secondary tyrosine kinase inhibitor resistance in gastrointestinal stromal tumor Mechanisms of resistance to imatinib and sunitinib in gastrointestinal stromal tumor.Bortezomib: killing two birds with one stone in gastrointestinal stromal tumors.Targeted therapy in GIST: in silico modeling for prediction of resistance.A potential role for nilotinib in KIT-mutated melanoma.STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis.Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia.miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours.Targeted polytherapy in small cell sarcoma and its association with doxorubicin.Novel Insights into the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors.Role of epigenetic modulation for the treatment of sarcoma.The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy.AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.Anti-KIT designer T cells for the treatment of gastrointestinal stromal tumor.Genetic progression in gastrointestinal stromal tumors: mechanisms and molecular interventions.Metastatic Cancer of Cowper's Gland: A Rare Cancer Managed Successfully by Molecular Profiling.Class 1-selective histone deacetylase inhibitors enhance HIV latency reversal while preserving the activity of HDAC isoforms necessary for maximal HIV gene expression.Emerging drugs for the treatment of gastrointestinal stromal tumour.New targets and therapies for gastrointestinal stromal tumors.Survivin is a novel transcription regulator of KIT and is downregulated by miRNA-494 in gastrointestinal stromal tumors.Evaluating the Effect of HDAC8 Inhibition in Malignant Peripheral Nerve Sheath Tumors.Silencing of adaptor protein SH3BP2 reduces KIT/PDGFRA receptors expression and impairs gastrointestinal stromal tumors growth.

P2860

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P1343

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P2860

Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.

http://www.wikidata.org/entity/Q39808264

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh

2009年學術文章

@zh-hant

name

Inhibitors of deacetylases sup ...... strointestinal stromal tumors.

@en

Inhibitors of deacetylases sup ...... strointestinal stromal tumors.

@nl

type

label

Inhibitors of deacetylases sup ...... strointestinal stromal tumors.

@en

Inhibitors of deacetylases sup ...... strointestinal stromal tumors.

@nl

prefLabel

Inhibitors of deacetylases sup ...... strointestinal stromal tumors.

@en

Inhibitors of deacetylases sup ...... strointestinal stromal tumors.

@nl

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0008-5472.CAN-08-4004

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Cancer Research

P1476

Inhibitors of deacetylases sup ...... strointestinal stromal tumors.

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P2093

Andrew J Wagner

http://www.w3.org/2001/XMLSchema#string

Florian Grabellus

http://www.w3.org/2001/XMLSchema#string

Georg Taeger

http://www.w3.org/2001/XMLSchema#string

Hauke Lang

http://www.w3.org/2001/XMLSchema#string

James Bradner

http://www.w3.org/2001/XMLSchema#string

Jonathan A Fletcher

http://www.w3.org/2001/XMLSchema#string

Martin Schuler

http://www.w3.org/2001/XMLSchema#string

Sebastian Bauer

http://www.w3.org/2001/XMLSchema#string

Takahiro Taguchi

http://www.w3.org/2001/XMLSchema#string

Thomas Mühlenberg

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P2860

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.

Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor.

Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate.

Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate.

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

The complex language of chromatin regulation during transcription

Histone deacetylases and cancer

Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial

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6941-6950

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apoptotic process

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2905726

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