The UL97 gene product of human cytomegalovirus is an early-late protein with a nuclear localization but is not a nucleoside kinase.
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Human cytomegalovirus resistance to antiviral drugsUpdate on human herpesvirus 6 biology, clinical features, and therapyCyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinasesAntiviral drug resistance of human cytomegalovirus.Novel mode of phosphorylation-triggered reorganization of the nuclear lamina during nuclear egress of human cytomegalovirusHuman cytomegalovirus UL97 Kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesisDNA microarrays of the complex human cytomegalovirus genome: profiling kinetic class with drug sensitivity of viral gene expression.An epistatic relationship between the viral protein kinase UL97 and the UL133-UL138 latency locus during the human cytomegalovirus lytic cycle.Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.Relationship between autophosphorylation and phosphorylation of exogenous substrates by the human cytomegalovirus UL97 protein kinase.Human cytomegalovirus UL97 kinase and nonkinase functions mediate viral cytoplasmic secondary envelopment.Lobucavir is phosphorylated in human cytomegalovirus-infected and -uninfected cells and inhibits the viral DNA polymeraseThe UL13 and US3 Protein Kinases of Herpes Simplex Virus 1 Cooperate to Promote the Assembly and Release of Mature, Infectious Virions.The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines.Human cytomegalovirus pUL97 kinase induces global changes in the infected cell phosphoproteome.RhoB is a component of the human cytomegalovirus assembly complex and is required for efficient viral production.Key motifs in EBV (Epstein-Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization.Conserved herpesvirus protein kinases.Human cytomegalovirus UL97 kinase alters the accumulation of CDK1.Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes.Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavirTegument proteins of human cytomegalovirusExpression of the human cytomegalovirus UL97 gene in a chimeric guinea pig cytomegalovirus (GPCMV) results in viable virus with increased susceptibility to ganciclovir and maribavir.Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.Expression and localization of the Epstein-Barr virus-encoded protein kinase.Differential properties of cytomegalovirus pUL97 kinase isoforms affect viral replication and maribavir susceptibilityViral serine/threonine protein kinasesRole of tegument proteins in herpesvirus assembly and egress.A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir.The U69 gene of human herpesvirus 6 encodes a protein kinase which can confer ganciclovir sensitivity to baculoviruses.The Cys607-->Tyr change in the UL97 phosphotransferase confers ganciclovir resistance to two human cytomegalovirus strains recovered from two immunocompromised patients.Comparison between human cytomegalovirus pUL97 and murine cytomegalovirus (MCMV) pM97 expressed by MCMV and vaccinia virus: pM97 does not confer ganciclovir sensitivity.A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency.Amino acids of conserved kinase motifs of cytomegalovirus protein UL97 are essential for autophosphorylation.RASCAL is a new human cytomegalovirus-encoded protein that localizes to the nuclear lamina and in cytoplasmic vesicles at late times postinfection.Flow cytometric analysis of herpes simplex virus type 1 susceptibility to acyclovir, ganciclovir, and foscarnet.Characterization of the human herpesvirus 6 U69 gene product and identification of its nuclear localization signal.The effects of maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 proteinEarly selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient.
P2860
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P2860
The UL97 gene product of human cytomegalovirus is an early-late protein with a nuclear localization but is not a nucleoside kinase.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
The UL97 gene product of human ...... ut is not a nucleoside kinase.
@en
The UL97 gene product of human ...... ut is not a nucleoside kinase.
@nl
type
label
The UL97 gene product of human ...... ut is not a nucleoside kinase.
@en
The UL97 gene product of human ...... ut is not a nucleoside kinase.
@nl
prefLabel
The UL97 gene product of human ...... ut is not a nucleoside kinase.
@en
The UL97 gene product of human ...... ut is not a nucleoside kinase.
@nl
P2093
P2860
P1433
P1476
The UL97 gene product of human ...... but is not a nucleoside kinase
@en
P2093
Heuschmid M
Wunderlich K
Zimmermann A
P2860
P304
P407
P577
1996-09-01T00:00:00Z