Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation.
about
Ceramide synthases at the centre of sphingolipid metabolism and biologySTAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancerSphingosine kinase activity is not required for tumor cell viabilitySilencing Fas-associated phosphatase 1 expression enhances efficiency of chemotherapy for colon carcinoma with oxaliplatinThe expression of sphingosine kinase-1 in head and neck carcinomaSphingosine kinase 1 in cancer.Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling.Apoptotic sphingolipid ceramide in cancer therapy.Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind HydeAn novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma.Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway.Targeting sphingosine kinase-1 to inhibit melanoma.Sphingosine kinase 1 as an anticancer therapeutic target.Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer.Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer CellsLiver acid sphingomyelinase inhibits growth of metastatic colon cancer.Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined.Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide productionAlkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage responseSphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population.Sphingolipids in colon cancer.An oncogenic role for sphingosine kinase 2.p53 and regulation of bioactive sphingolipids.Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.Oncogenic properties of sphingosine kinases in haematological malignancies.Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription.Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.LoVo colon cancer cells resistant to oxaliplatin overexpress c-MET and VEGFR-1 and respond to VEGF with dephosphorylation of c-MET.Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer.Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways.Long noncoding RNA CRNDE functions as a competing endogenous RNA to promote metastasis and oxaliplatin resistance by sponging miR-136 in colorectal cancer.Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer.Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice.Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor.
P2860
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P2860
Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Sphingosine kinase isoforms re ...... cumulation and Akt activation.
@en
Sphingosine kinase isoforms re ...... cumulation and Akt activation.
@nl
type
label
Sphingosine kinase isoforms re ...... cumulation and Akt activation.
@en
Sphingosine kinase isoforms re ...... cumulation and Akt activation.
@nl
prefLabel
Sphingosine kinase isoforms re ...... cumulation and Akt activation.
@en
Sphingosine kinase isoforms re ...... cumulation and Akt activation.
@nl
P2093
P2860
P356
P1476
Sphingosine kinase isoforms re ...... ccumulation and Akt activation
@en
P2093
Akira Hara
Hiroshi Ueda
Satoshi Nemoto
Takashi Murate
Yoshiko Banno
Yoshinori Itoh
Yoshinori Nozawa
Yosuke Osawa
Yukio Okano
P2860
P304
10422-10432
P356
10.1074/JBC.M900735200
P407
P577
2009-02-24T00:00:00Z