Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation. - Wikidata - wikimedia - TriplyDB

Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation.

Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation.

http://www.wikidata.org/entity/Q39880179

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Ceramide synthases at the centre of sphingolipid metabolism and biology STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer Sphingosine kinase activity is not required for tumor cell viability Silencing Fas-associated phosphatase 1 expression enhances efficiency of chemotherapy for colon carcinoma with oxaliplatin The expression of sphingosine kinase-1 in head and neck carcinoma Sphingosine kinase 1 in cancer.Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling.Apoptotic sphingolipid ceramide in cancer therapy.Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma.Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway.Targeting sphingosine kinase-1 to inhibit melanoma.Sphingosine kinase 1 as an anticancer therapeutic target.Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer.Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells Liver acid sphingomyelinase inhibits growth of metastatic colon cancer.Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined.Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population.Sphingolipids in colon cancer.An oncogenic role for sphingosine kinase 2.p53 and regulation of bioactive sphingolipids.Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.Oncogenic properties of sphingosine kinases in haematological malignancies.Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription.Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.LoVo colon cancer cells resistant to oxaliplatin overexpress c-MET and VEGFR-1 and respond to VEGF with dephosphorylation of c-MET.Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer.Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways.Long noncoding RNA CRNDE functions as a competing endogenous RNA to promote metastasis and oxaliplatin resistance by sponging miR-136 in colorectal cancer.Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer.Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice.Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor.

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Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation.

http://www.wikidata.org/entity/Q39880179

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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name

Sphingosine kinase isoforms re ...... cumulation and Akt activation.

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Sphingosine kinase isoforms re ...... cumulation and Akt activation.

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type

label

Sphingosine kinase isoforms re ...... cumulation and Akt activation.

@en

Sphingosine kinase isoforms re ...... cumulation and Akt activation.

@nl

prefLabel

Sphingosine kinase isoforms re ...... cumulation and Akt activation.

@en

Sphingosine kinase isoforms re ...... cumulation and Akt activation.

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P1433

Journal of Biological Chemistry

P1476

Sphingosine kinase isoforms re ...... ccumulation and Akt activation

@en

P2093

Akira Hara

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Hiroshi Ueda

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Saki Kono

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Satoshi Nemoto

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Takashi Murate

http://www.w3.org/2001/XMLSchema#string

Yoshiko Banno

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Yoshinori Itoh

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Yoshinori Nozawa

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Yosuke Osawa

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Yukio Okano

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P2860

(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

p53 mutations in human cancers

Sphingosine-1-phosphate: an enigmatic signalling lipid

Discovery and evaluation of inhibitors of human sphingosine kinase.

Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.

Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas.

Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.

Role of sphingosine kinase 2 in cell migration toward epidermal growth factor.

P304

10422-10432

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10.1074/JBC.M900735200

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P433

16

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284

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Mitsuhiro Nakamura

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2009-02-24T00:00:00Z

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19240026

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2667729

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