(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1
about
Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processingCeramide synthases at the centre of sphingolipid metabolism and biologyMammalian ceramide synthasesA critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathyRoles of bioactive sphingolipids in cancer biology and therapeuticsEvolving concepts in cancer therapy through targeting sphingolipid metabolismAntiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cellsThe BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.Extracellular and intracellular actions of sphingosine-1-phosphateSelective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolismDoes cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell KillingSphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.Many ceramides.Enhanced tumor cures after Foscan photodynamic therapy combined with the ceramide analog LCL29. Evidence from mouse squamous cell carcinomas for sphingolipids as biomarkers of treatment response.Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells.Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response.Sphingolipids: regulators of crosstalk between apoptosis and autophagyIncreased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas.Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight.Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation.RNAi-mediated functional analysis of pathways influencing cancer cell drug resistance.siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy.Pharmacogenetics of resistance to Cisplatin and other anticancer drugs and the role of sphingolipid metabolism.Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistanceSphingolipids in the DNA damage response.Sphingolipids and mitochondrial apoptosis.Ceramide synthases in mammalians, worms, and insects: emerging schemes.Anticancer potential of sanguinarine for various human malignancies.Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.Sphingolipids in mitochondria.Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity.Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation.Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection.Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.Sphingosine kinase 1 regulates measles virus replication.Ceramide synthase 1 is regulated by proteasomal mediated turnoverCurcumin affects gene expression and reactive oxygen species via a PKA dependent mechanism in Dictyostelium discoideum.
P2860
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P2860
(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@ast
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@en
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@en-gb
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@nl
type
label
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@ast
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@en
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@en-gb
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@nl
prefLabel
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@ast
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@en
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@en-gb
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@nl
P2093
P50
P1476
(Dihydro)ceramide synthase 1 r ...... ogated by sphingosine kinase 1
@en
P2093
Adi Mesika
Hannah Alexander
Paul P Van Veldhoven
Stephen Alexander
P304
P356
10.1158/1541-7786.MCR-07-0100
P407
P577
2007-08-01T00:00:00Z