The UL84 protein of human cytomegalovirus acts as a transdominant inhibitor of immediate-early-mediated transactivation that is able to prevent viral replication.
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Functional interaction between pleiotropic transactivator pUL69 of human cytomegalovirus and the human homolog of yeast chromatin regulatory protein SPT6A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathwayCytomegalovirus antivirals and development of improved animal modelsA novel transferable nuclear export signal mediates CRM1-independent nucleocytoplasmic shuttling of the human cytomegalovirus transactivator protein pUL69Inhibition of human cytomegalovirus replication via peptide aptamers directed against the nonconventional nuclear localization signal of the essential viral replication factor pUL84.Open reading frame UL26 of human cytomegalovirus encodes a novel tegument protein that contains a strong transcriptional activation domain.Identification of human cytomegalovirus UL84 virus- and cell-encoded binding partners by using proteomics analysisActivation of transcription of the human cytomegalovirus early UL4 promoter by the Ets transcription factor binding element.In vivo replication, latency, and immunogenicity of murine cytomegalovirus mutants with deletions in the M83 and M84 genes, the putative homologs of human cytomegalovirus pp65 (UL83).A cis repression sequence adjacent to the transcription start site of the human cytomegalovirus US3 gene is required to down regulate gene expression at early and late times after infectionCovalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b.The human cytomegalovirus IE86 protein can block cell cycle progression after inducing transition into the S phase of permissive cells.Analysis and characterization of the complete genome of tupaia (tree shrew) herpesvirusConstruction of a rationally designed human cytomegalovirus variant encoding a temperature-sensitive immediate-early 2 protein.Functional interaction between the pp71 protein of human cytomegalovirus and the PML-interacting protein human Daxx.Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteinsInteraction network of proteins associated with human cytomegalovirus IE2-p86 protein during infection: a proteomic analysis.Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32.Human cytomegalovirus UL84 interacts with an RNA stem-loop sequence found within the RNA/DNA hybrid region of oriLyt.An endogenous accelerator for viral gene expression confers a fitness advantage.Cleavage specificity of the UL48 deubiquitinating protease activity of human cytomegalovirus and the growth of an active-site mutant virus in cultured cells.Human cytomegalovirus UL76 encodes a novel virion-associated protein that is able to inhibit viral replication.Dynamic and nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication compartments and nucleoli.Human cytomegalovirus UL84 protein contains two nuclear export signals and shuttles between the nucleus and the cytoplasmGenetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during Culture In Vitro.A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localizationCharacterization of the transcriptional repressive element of the human cytomegalovirus immediate-early US3 gene.Identification of a novel transcriptional repressor encoded by human cytomegalovirus.Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV.Human cytomegalovirus UL84 localizes to the cell nucleus via a nuclear localization signal and is a component of viral replication compartments.Human cytomegalovirus IE2 86 and IE2 40 proteins differentially regulate UL84 protein expression posttranscriptionally in the absence of other viral gene products.Human cytomegalovirus UL84 oligomerization and heterodimerization domains act as transdominant inhibitors of oriLyt-dependent DNA replication: evidence that IE2-UL84 and UL84-UL84 interactions are required for lytic DNA replicationHuman cytomegalovirus tegument proteins ppUL82 (pp71) and ppUL35 interact and cooperatively activate the major immediate-early enhancer.Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses.Interaction of HCMV UL84 with C/EBPalpha transcription factor binding sites within oriLyt is essential for lytic DNA replication.Internal deletions of IE2 86 and loss of the late IE2 60 and IE2 40 proteins encoded by human cytomegalovirus affect the levels of UL84 protein but not the amount of UL84 mRNA or the loading and distribution of the mRNA on polysomesHuman cytomegalovirus UL84 insertion mutant defective for viral DNA synthesis and growth.Human cytomegalovirus DNA replication requires transcriptional activation via an IE2- and UL84-responsive bidirectional promoter element within oriLyt.Small internal deletions in the human cytomegalovirus IE2 gene result in nonviable recombinant viruses with differential defects in viral gene expression.New genes from old: redeployment of dUTPase by herpesviruses.
P2860
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P2860
The UL84 protein of human cytomegalovirus acts as a transdominant inhibitor of immediate-early-mediated transactivation that is able to prevent viral replication.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
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1997年學術文章
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1997年學術文章
@zh-hant
name
The UL84 protein of human cyto ...... to prevent viral replication.
@en
The UL84 protein of human cyto ...... to prevent viral replication.
@nl
type
label
The UL84 protein of human cyto ...... to prevent viral replication.
@en
The UL84 protein of human cyto ...... to prevent viral replication.
@nl
prefLabel
The UL84 protein of human cyto ...... to prevent viral replication.
@en
The UL84 protein of human cyto ...... to prevent viral replication.
@nl
P2093
P2860
P1433
P1476
The UL84 protein of human cyto ...... e to prevent viral replication
@en
P2093
P2860
P304
P407
P577
1997-09-01T00:00:00Z