Construction of a rationally designed human cytomegalovirus variant encoding a temperature-sensitive immediate-early 2 protein.
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Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expressionAn HIV feedback resistor: auto-regulatory circuit deactivator and noise bufferProlonged activation of NF-kappaB by human cytomegalovirus promotes efficient viral replication and late gene expressionElimination of ie1 significantly attenuates murine cytomegalovirus virulence but does not alter replicative capacity in cell cultureExon 3 of the human cytomegalovirus major immediate-early region is required for efficient viral gene expression and for cellular cyclin modulation.Functional map of human cytomegalovirus AD169 defined by global mutational analysis.Functional properties of the human cytomegalovirus IE86 protein required for transcriptional regulation and virus replicationReal-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infectionStrain variations in single amino acids of the 86-kilodalton human cytomegalovirus major immediate-early protein (IE2) affect its functional and biochemical properties: implications of dynamic protein conformation.SUMOylation of the human cytomegalovirus 72-kilodalton IE1 protein facilitates expression of the 86-kilodalton IE2 protein and promotes viral replicationRat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitroHuman Cytomegalovirus gH/gL/gO Promotes the Fusion Step of Entry into All Cell Types, whereas gH/gL/UL128-131 Broadens Virus Tropism through a Distinct Mechanism.The full-length protein encoded by human cytomegalovirus gene UL117 is required for the proper maturation of viral replication compartments.Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus.Physical requirements and functional consequences of complex formation between the cytomegalovirus IE1 protein and human STAT2.Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteinsHuman cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation.Conditional cytomegalovirus replication in vitro and in vivo.The human cytomegalovirus major immediate-early proteins as antagonists of intrinsic and innate antiviral host responses.Transient Oral Human Cytomegalovirus Infections Indicate Inefficient Viral Spread from Very Few Initially Infected Cells.Dynamics of Persistent Oral Cytomegalovirus Shedding During Primary Infection in Ugandan Infants.Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication.The human cytomegalovirus UL82 gene product (pp71) accelerates progression through the G1 phase of the cell cycle.Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses.The putative zinc finger of the human cytomegalovirus IE2 86-kilodalton protein is dispensable for DNA binding and autorepression, thereby demarcating a concise core domain in the C terminus of the protein.Small internal deletions in the human cytomegalovirus IE2 gene result in nonviable recombinant viruses with differential defects in viral gene expression.Two gamma interferon-activated site-like elements in the human cytomegalovirus major immediate-early promoter/enhancer are important for viral replication.Human cytomegalovirus early protein pUL21a promotes efficient viral DNA synthesis and the late accumulation of immediate-early transcripts.miRNA-mediated targeting of human cytomegalovirus reveals biological host and viral targets of IE2.Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus
P2860
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P2860
Construction of a rationally designed human cytomegalovirus variant encoding a temperature-sensitive immediate-early 2 protein.
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Construction of a rationally d ...... ive immediate-early 2 protein.
@ast
Construction of a rationally d ...... ive immediate-early 2 protein.
@en
Construction of a rationally d ...... ive immediate-early 2 protein.
@nl
type
label
Construction of a rationally d ...... ive immediate-early 2 protein.
@ast
Construction of a rationally d ...... ive immediate-early 2 protein.
@en
Construction of a rationally d ...... ive immediate-early 2 protein.
@nl
prefLabel
Construction of a rationally d ...... ive immediate-early 2 protein.
@ast
Construction of a rationally d ...... ive immediate-early 2 protein.
@en
Construction of a rationally d ...... ive immediate-early 2 protein.
@nl
P2093
P2860
P356
P1476
Construction of a rationally d ...... ive immediate-early 2 protein.
@en
P2093
Julie A Heider
Thomas E Shenk
Wade A Bresnahan
P2860
P304
P356
10.1073/PNAS.052710599
P407
P577
2002-02-26T00:00:00Z