A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.
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Tregalizumab - A Monoclonal Antibody to Target Regulatory T CellsNeuroimmunotherapies Targeting T Cells: From Pathophysiology to Therapeutic Applications.Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice.High thioredoxin-1 levels in rheumatoid arthritis patients diminish binding and signalling of the monoclonal antibody TregalizumabAttenuation of graft-versus-host-disease in NOD scid IL-2Rγ(-/-) (NSG) mice by ex vivo modulation of human CD4(+) T cells.Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells.Moderate to severe psoriasis treatment challenges through the era of biological drugs.Novel Concept of CD4-Mediated Activation of Regulatory T Cells for the Treatment of Graft-Versus-Host Disease.Th17/Treg immunoregulation and implications in treatment of sulfur mustard gas-induced lung diseases.Self-Recognition Sensitizes Mouse and Human Regulatory T Cells to Low-Dose CD28 Superagonist Stimulation.Lenalidomide potentiates CD4+CD25+Treg-related suppression of lymphoma B-cell proliferation.Incubation of Immune Cell Grafts With MAX.16H5 IgG1 Anti-Human CD4 Antibody Prolonged Survival After Hematopoietic Stem Cell Transplantation in a Mouse Model for Fms Like Tyrosine Kinase 3 Positive Acute Myeloid Leukemia
P2860
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P2860
A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.
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A specific CD4 epitope bound b ...... by a unique signaling pathway.
@en
A specific CD4 epitope bound b ...... by a unique signaling pathway.
@nl
type
label
A specific CD4 epitope bound b ...... by a unique signaling pathway.
@en
A specific CD4 epitope bound b ...... by a unique signaling pathway.
@nl
prefLabel
A specific CD4 epitope bound b ...... by a unique signaling pathway.
@en
A specific CD4 epitope bound b ...... by a unique signaling pathway.
@nl
P2093
P2860
P50
P356
P1476
A specific CD4 epitope bound b ...... by a unique signaling pathway.
@en
P2093
Andre Engling
Benjamin Dälken
Bianca Helling
Brigitte Fritz
Brigitte Wildemann
Christoph Uherek
Frank Osterroth
Holger Wallmeier
Jan Kubach
Katharina Heim
P2860
P304
P356
10.1038/ICB.2014.102
P577
2014-12-16T00:00:00Z