Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure.
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Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complexTetrameric structure of SUR2B revealed by electron microscopy of oriented single particlesEngineered Kir6.2 mutations that correct the trafficking defect of K(ATP) channels caused by specific SUR1 mutationsImpact of disease-causing SUR1 mutations on the KATP channel subunit interface probed with a rhodamine protection assay.Neonatal diabetes caused by mutations in sulfonylurea receptor 1: interplay between expression and Mg-nucleotide gating defects of ATP-sensitive potassium channels.N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation.Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in KATP channels.Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels.Molecular biology of K(ATP) channels and implications for health and disease.Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.ATP activates ATP-sensitive potassium channels composed of mutant sulfonylurea receptor 1 and Kir6.2 with diminished PIP2 sensitivityLKB1 couples glucose metabolism to insulin secretion in mice.Sodium 4-phenylbutyrate ameliorates the effects of cataract-causing mutant gammaD-crystallin in cultured cells.Pharmacological Correction of Trafficking Defects in ATP-sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations.Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM.
P2860
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P2860
Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure.
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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name
Sulfonylurea receptor 1 mutati ...... h chemical chaperone exposure.
@en
Sulfonylurea receptor 1 mutati ...... h chemical chaperone exposure.
@nl
type
label
Sulfonylurea receptor 1 mutati ...... h chemical chaperone exposure.
@en
Sulfonylurea receptor 1 mutati ...... h chemical chaperone exposure.
@nl
prefLabel
Sulfonylurea receptor 1 mutati ...... h chemical chaperone exposure.
@en
Sulfonylurea receptor 1 mutati ...... h chemical chaperone exposure.
@nl
P2093
P2860
P356
P1476
Sulfonylurea receptor 1 mutati ...... h chemical chaperone exposure.
@en
P2093
Emily B Pratt
Fei-Fei Yan
Joel W Gay
Show-Ling Shyng
P2860
P304
P356
10.1074/JBC.M807012200
P407
P577
2009-01-16T00:00:00Z