Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers.
about
JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indicationsAsparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis)Identification of a novel functional JAK1 S646P mutation in acute lymphoblastic leukemia.Overexpression of IL-9 induced by STAT6 activation promotes the pathogenesis of chronic lymphocytic leukemia.Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors.Activation of JAK2-V617F by components of heterodimeric cytokine receptorsCRLF2 and JAK2 in B-progenitor acute lymphoblastic leukemia: a novel association in oncogenesis.The role of interleukin-9 in lymphoma.Association between low expression levels of interleukin-9 and colon cancer progression.Distinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities.Potential roles of IL-9 in the pathogenesis of systemic lupus erythematosusWhole-genome sequencing identifies recurrent mutations in hepatocellular carcinomaComparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia.Role of high expression of IL-9 in prognosis of CLL.Sex chromosome loss and the pseudoautosomal region genes in hematological malignancies.From bench to bedside: Therapeutic potential of interleukin-9 in the treatment of asthmaJAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia.Activating Janus kinase pseudokinase domain mutations in myeloproliferative and other blood cancers.Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.JAK/STAT pathway directed therapy of T-cell leukemia/lymphoma: Inspired by functional and structural genomics.Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia.Evaluation of Interleukin-9 Expression as a Potential Therapeutic Target in Chronic Lymphocytic Leukemia in a Cohort of Egyptian Patients.Sex chromosome changes in leukemia: cytogenetics and molecular aspects.JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders.The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models
P2860
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P2860
Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Acute lymphoblastic leukemia-a ...... n-9 receptor alpha homodimers.
@en
Acute lymphoblastic leukemia-a ...... n-9 receptor alpha homodimers.
@nl
type
label
Acute lymphoblastic leukemia-a ...... n-9 receptor alpha homodimers.
@en
Acute lymphoblastic leukemia-a ...... n-9 receptor alpha homodimers.
@nl
prefLabel
Acute lymphoblastic leukemia-a ...... n-9 receptor alpha homodimers.
@en
Acute lymphoblastic leukemia-a ...... n-9 receptor alpha homodimers.
@nl
P2093
P2860
P50
P356
P1476
Acute lymphoblastic leukemia-a ...... n-9 receptor alpha homodimers.
@en
P2093
Elisabetta Flex
Judith Staerk
Laurent Knoops
Tekla Hornakova
Yohan Royer
P2860
P304
P356
10.1074/JBC.M807531200
P407
P577
2009-01-12T00:00:00Z