FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
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The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γFBXW7-mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cellsPI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activityFbxw7 regulates lipid metabolism and cell fate decisions in the mouse liverFAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7UBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor geneMicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cellsPerifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagyCullin-RING ligases in regulation of autophagyFbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human TumorigenesisRevealing the Complexity of Breast Cancer by Next Generation SequencingThe role of the ubiquitin proteasome system in cerebellar development and medulloblastomaAdaptive resistance to targeted therapies in cancerTargeting the ubiquitin pathway for cancer treatmentTNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagyA genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors.Dysregulation of ubiquitin ligases in cancerDEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagyREDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligaseGenome remodelling in a basal-like breast cancer metastasis and xenograftFBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradationTargeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis.Nanoscale obstacle arrays frustrate transport of EphA2-Ephrin-A1 clusters in cancer cell linesEnhancing mTOR-targeted cancer therapy.FBXW7 expression is associated with prognosis and chemotherapeutic outcome in Chinese patients with gastric adenocarcinomaFbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma.Aberrant regulation of FBW7 in cancer.Macrophage infiltration and genetic landscape of undifferentiated uterine sarcomas.Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer.FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma.The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs.Gene-expression signature predicts postoperative recurrence in stage I non-small cell lung cancer patients.Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibilityThe NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.F-box protein FBXO31 is down-regulated in gastric cancer and negatively regulated by miR-17 and miR-20a.RORα suppresses breast tumor invasion by inducing SEMA3F expressionAmino acid-induced impairment of insulin sensitivity in healthy and obese rats is reversible.
P2860
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P2860
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
@en
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
@nl
type
label
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
@en
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
@nl
prefLabel
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
@en
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
@nl
P2093
P2860
P356
P1433
P1476
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
@en
P2093
Allan Balmain
Hio Chung Kang
Il-Jin Kim
Joan Climent
Reyno DelRosario
P2860
P304
P356
10.1126/SCIENCE.1162981
P407
P50
P577
2008-09-01T00:00:00Z