The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. - Wikidata - wikimedia - TriplyDB

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.

http://www.wikidata.org/entity/Q39934103

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Modulating splicing with small molecular inhibitors of the spliceosome Age-related nuclear translocation of P2X6 subunit modifies splicing activity interacting with splicing factor 3A1 Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment RNA and disease Mitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus.Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay.Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.Antimicrobial activity, toxicity and selectivity index of two biflavonoids and a flavone isolated from Podocarpus henkelii (Podocarpaceae) leaves.Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms Translation of pre-spliced RNAs in the nuclear compartment generates peptides for the MHC class I pathway The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region.A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomes SnapShot-Seq: a method for extracting genome-wide, in vivo mRNA dynamics from a single total RNA sample Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.Identification of small molecule inhibitors of pre-mRNA splicing.The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis.High-throughput single-molecule screen for small-molecule perturbation of splicing and transcription kinetics.The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B mRNA transcript diversity creates new opportunities for pharmacological intervention.The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing.Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy Oncogenic alternative splicing switches: role in cancer progression and prospects for therapy.Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells.Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogens.Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.Splicing in oncogenesis and tumor suppression.Pre-mRNA splicing in disease and therapeutics.Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia.Modulation of alternative splicing by anticancer drugs.Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.Pre-mRNA splicing repression triggers abiotic stress signaling in plants.Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing.The differential interaction of snRNPs with pre-mRNA reveals splicing kinetics in living cells.Widespread intron retention diversifies most cancer transcriptomes.Splicing controls the ubiquitin response during DNA double-strand break repair.Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP.Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A Molecular architecture of zinc chelating small molecules that inhibit spliceosome assembly at an early stage.

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P2860

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.

http://www.wikidata.org/entity/Q39934103

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

2008年论文

@zh

2008年论文

@zh-cn

name

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.

@en

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.

@nl

type

label

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.

@en

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.

@nl

prefLabel

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.

@en

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.

@nl

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P1433

Journal of Biological Chemistry

P1476

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.

@en

P2093

April M Lowell

http://www.w3.org/2001/XMLSchema#string

Arianne J Matlin

http://www.w3.org/2001/XMLSchema#string

Kristine O'Brien

http://www.w3.org/2001/XMLSchema#string

Melissa J Moore

http://www.w3.org/2001/XMLSchema#string

P2860

Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Interactions of the yeast SF3b splicing factor.

A novel spliceosome containing U11, U12, and U5 snRNPs excises a minor class (AT-AC) intron in vitro

Small-molecule inhibition of HIV pre-mRNA splicing as a novel antiretroviral therapy to overcome drug resistance

Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes

Use of transcriptional synergy to augment sensitivity of a splicing reporter assay

Searching for a wrench to throw into the splicing machine.

A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

P304

33147-33154

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scholarly article

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10.1074/JBC.M805556200

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P407

P433

48

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P478

283

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P577

2008-09-30T00:00:00Z

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18826947

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P932

2586251

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