The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
about
Modulating splicing with small molecular inhibitors of the spliceosomeAge-related nuclear translocation of P2X6 subunit modifies splicing activity interacting with splicing factor 3A1Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer TreatmentRNA and diseaseMitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus.Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay.Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.Antimicrobial activity, toxicity and selectivity index of two biflavonoids and a flavone isolated from Podocarpus henkelii (Podocarpaceae) leaves.Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoformsTranslation of pre-spliced RNAs in the nuclear compartment generates peptides for the MHC class I pathwayThe anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region.A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomesSnapShot-Seq: a method for extracting genome-wide, in vivo mRNA dynamics from a single total RNA sampleMotor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.Identification of small molecule inhibitors of pre-mRNA splicing.The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human SpliceosomesA quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis.High-throughput single-molecule screen for small-molecule perturbation of splicing and transcription kinetics.The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2BmRNA transcript diversity creates new opportunities for pharmacological intervention.The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing.Small Molecule Modulators of Pre-mRNA Splicing in Cancer TherapyOncogenic alternative splicing switches: role in cancer progression and prospects for therapy.Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells.Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogens.Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.Splicing in oncogenesis and tumor suppression.Pre-mRNA splicing in disease and therapeutics.Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia.Modulation of alternative splicing by anticancer drugs.Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.Pre-mRNA splicing repression triggers abiotic stress signaling in plants.Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing.The differential interaction of snRNPs with pre-mRNA reveals splicing kinetics in living cells.Widespread intron retention diversifies most cancer transcriptomes.Splicing controls the ubiquitin response during DNA double-strand break repair.Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP.Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin AMolecular architecture of zinc chelating small molecules that inhibit spliceosome assembly at an early stage.
P2860
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P2860
The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
@en
The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
@nl
type
label
The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
@en
The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
@nl
prefLabel
The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
@en
The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
@nl
P2093
P2860
P356
P1476
The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
@en
P2093
April M Lowell
Arianne J Matlin
Kristine O'Brien
Melissa J Moore
P2860
P304
33147-33154
P356
10.1074/JBC.M805556200
P407
P577
2008-09-30T00:00:00Z