Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells. - Wikidata - wikimedia - TriplyDB

Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells.

Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells.

http://www.wikidata.org/entity/Q39936976

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Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway Mnk kinase pathway: Cellular functions and biological outcomes Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway The circadian clock coordinates ribosome biogenesis Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma.Recombinant human erythropoietin stimulates melanoma tumor growth through activation of initiation factor eIF4E.Targeting the translational machinery as a novel treatment strategy for hematologic malignancies Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1.The class I PI3K/Akt pathway is critical for cancer cell survival in dogs and offers an opportunity for therapeutic intervention The role of c-Src in integrin (α6β4) dependent translational control YB-1 synthesis is regulated by mTOR signaling pathway.Translational control of cyclins.The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival Phosphorylated Mnk1 and eIF4E are associated with lymph node metastasis and poor prognosis of nasopharyngeal carcinoma.Prioritizing candidate disease metabolites based on global functional relationships between metabolites in the context of metabolic pathways.Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F (eIF4F) complex and up-regulates host translation initiation machinery through eIF4E-binding protein 1 inactivation.Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer Dual modulation of Ras-Mnk and PI3K-AKT-mTOR pathways: A Novel c-FLIP inhibitory mechanism of 3-AWA mediated translational attenuation through dephosphorylation of eIF4E.Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.The Extracellular-Regulated Kinase Effector Lk6 is Required for Glutamate Receptor Localization at the Drosophila Neuromuscular Junction.Prediction of functional phosphorylation sites by incorporating evolutionary information Adaptations to chronic rapamycin in mice.Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.Regulation of protein degradation pathways by amino acids and insulin in skeletal muscle of neonatal pigs.MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.Alternative splicing programs in prostate cancer.Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond.Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers.Targeting translation: eIF4E as an emerging anticancer drug target.Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion.Unveiling new chemical scaffolds as Mnk inhibitors.Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines.Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition.

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Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells.

http://www.wikidata.org/entity/Q39936976

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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name

Phosphorylation of eIF4E by MN ...... tion in prostate cancer cells.

@en

Phosphorylation of eIF4E by MN ...... tion in prostate cancer cells.

@nl

type

label

Phosphorylation of eIF4E by MN ...... tion in prostate cancer cells.

@en

Phosphorylation of eIF4E by MN ...... tion in prostate cancer cells.

@nl

prefLabel

Phosphorylation of eIF4E by MN ...... tion in prostate cancer cells.

@en

Phosphorylation of eIF4E by MN ...... tion in prostate cancer cells.

@nl

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Phosphorylation of eIF4E by MN ...... tion in prostate cancer cells.

@en

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Andrea Bianchini

http://www.w3.org/2001/XMLSchema#string

Fabrizio Loreni

http://www.w3.org/2001/XMLSchema#string

Maria Loiarro

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Roberta Busà

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P2860

PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis

PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

AKT/PKB signaling: navigating downstream

Pten dose dictates cancer progression in the prostate

TOR signaling in growth and metabolism

The biology and clinical relevance of the PTEN tumor suppressor pathway

Upstream and downstream of mTOR

The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells

PCNA, the maestro of the replication fork

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2279-2288

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scholarly article

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10.1093/CARCIN/BGN221

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12

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29

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Maria Paola Paronetto

Raffaele Geremia

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2008-09-22T00:00:00Z

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23273006

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18809972

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phosphorylation