Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. - Wikidata - wikimedia - TriplyDB

Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.

Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.

http://www.wikidata.org/entity/Q39941671

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Biomechanical factors in osteoarthritis Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructs Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1.Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes Role of IL-38 and its related cytokines in inflammation Biomechanical influence of cartilage homeostasis in health and disease The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds.Mechanotransduction and cartilage integrity.Osteoarthritis and obesity: experimental models.Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-α and interleukin-6, but accentuates degradation above a strain threshold.The involvement and possible mechanism of NR4A1 in chondrocyte apoptosis during osteoarthritis.Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model.Metabolic syndrome meets osteoarthritis.Pharmacological treatment with diacerein combined with mechanical stimulation affects the expression of growth factors in human chondrocytes.Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation.Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage.Cell type-specific suppression of mechanosensitive genes by audible sound stimulation.Numerical assessment on the effective mechanical stimuli for matrix-associated metabolism in chondrocyte-seeded constructs.Three hours of perfusion culture prior to 28 days of static culture, enhances osteogenesis by human cells in a collagen GAG scaffold

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P2860

Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.

http://www.wikidata.org/entity/Q39941671

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2008 nî lūn-bûn

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Dynamic compression counteract ...... hondrocyte/agarose constructs.

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Dynamic compression counteract ...... hondrocyte/agarose constructs.

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Dynamic compression counteract ...... hondrocyte/agarose constructs.

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Dynamic compression counteract ...... hondrocyte/agarose constructs.

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Arthritis Research and Therapy

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Dynamic compression counteract ...... chondrocyte/agarose constructs

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D L Bader

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D M Salter

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J Brand

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O O Akanji

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S Arghandawi

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P2860

Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes

Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage

Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP

Integrin-dependent signal cascades in chondrocyte mechanotransduction

Quantification of mRNA using real-time RT-PCR

Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

The effect of cyclical compressive loading on gene expression in articular cartilage.

Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain.

Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes.

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10.1186/AR2389

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