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Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics.Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression.Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels.Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading.Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations.The metabolism of human mesenchymal stem cells during proliferation and differentiation.Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem CellsMechanical regulation of nuclear structure and function.Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity.Oxygen tension modulates the effects of TNFα in compressed chondrocytesStem cell mechanobiology.Dynamic regulation of nuclear architecture and mechanics-a rheostatic role for the nucleus in tailoring cellular mechanosensitivity.Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells.Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygenElectrospray deposited fibronectin retains the ability to promote cell adhesion.Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields.Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.Mechanical conditioning influences the metabolic response of cell-seeded constructs.Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture.Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment.Both superficial and deep zone articular chondrocyte subpopulations exhibit the Crabtree effect but have different basal oxygen consumption rates.Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration.Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles.Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes.Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs.Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques.Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression.Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs.Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels.Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes.Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs.Quantification of chromatin condensation level by image processing.Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes.Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression.Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment.Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach.Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes.Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs.Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro.An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties.
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
@en
հետազոտող
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name
David A. Lee
@ast
David A. Lee
@en
David A. Lee
@es
David A. Lee
@nl
David A. Lee
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type
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David A. Lee
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David A. Lee
@en
David A. Lee
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David A. Lee
@nl
David A. Lee
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prefLabel
David A. Lee
@ast
David A. Lee
@en
David A. Lee
@es
David A. Lee
@nl
David A. Lee
@sl
P106
P1153
36071667600
55619306275
P21
P31
P496
0000-0001-7646-4643