Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase.
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Structure and function of biotin-dependent carboxylasesInteraction between the Biotin Carboxyl Carrier Domain and the Biotin Carboxylase Domain in Pyruvate Carboxylase from Rhizobium etliMitochondrial pyruvate transport: a historical perspective and future research directionsKnockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cellsLower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cellsLiver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.Plasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics.Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K miceMitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretionDifferential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesityRat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells.Regulation of insulin secretion: role of mitochondrial signalling.Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive elementGlutamine addiction: a new therapeutic target in cancerPyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.Cryo-EM analysis reveals new insights into the mechanism of action of pyruvate carboxylase.The role of biotin and oxamate in the carboxyltransferase reaction of pyruvate carboxylaseß-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretionMechanisms of inhibition of Rhizobium etli pyruvate carboxylase by L-aspartateCharacterization of the distal promoter of the human pyruvate carboxylase gene in pancreatic beta cells.Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic ß-cells.Geniposide regulates glucose-stimulated insulin secretion possibly through controlling glucose metabolism in INS-1 cells.Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cellsThe complex mechanism of glutamate dehydrogenase in insulin secretion.Characterization of phospholipids in insulin secretory granules and mitochondria in pancreatic beta cells and their changes with glucose stimulation.Inhibitors of Pyruvate CarboxylaseSphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell lineThe role of mitochondria in the pathogenesis of type 2 diabetesMass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETIONLoss of coupling between calcium influx, energy consumption and insulin secretion associated with development of hyperglycaemia in the UCD-T2DM rat model of type 2 diabetes.Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndromeChronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line.Insulin release, peripheral insulin resistance and muscle function in protein malnutrition: a role of tricarboxylic acid cycle anaplerosis.The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells.Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion.Aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor-1{beta} plays a critical role in maintaining glucose-stimulated anaplerosis and insulin release from pancreatic {beta}-cells.Glucose induces expression of rat pyruvate carboxylase through a carbohydrate response element in the distal gene promoter.
P2860
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P2860
Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Impaired anaplerosis and insul ...... ssion of pyruvate carboxylase.
@en
Impaired anaplerosis and insul ...... ssion of pyruvate carboxylase.
@nl
type
label
Impaired anaplerosis and insul ...... ssion of pyruvate carboxylase.
@en
Impaired anaplerosis and insul ...... ssion of pyruvate carboxylase.
@nl
prefLabel
Impaired anaplerosis and insul ...... ssion of pyruvate carboxylase.
@en
Impaired anaplerosis and insul ...... ssion of pyruvate carboxylase.
@nl
P2093
P2860
P356
P1476
Impaired anaplerosis and insul ...... ssion of pyruvate carboxylase.
@en
P2093
John C Wallace
Melissa J Longacre
Michael J MacDonald
Mindy A Kendrick
Noaman M Hasan
Sarawut Jitrapakdee
Scott W Stoker
Thirajit Boonsaen
P2860
P304
28048-28059
P356
10.1074/JBC.M804170200
P407
P577
2008-08-12T00:00:00Z