13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS) - Wikidata - wikimedia - TriplyDB

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

http://www.wikidata.org/entity/Q24530767

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Stable isotope-resolved metabolomics and applications for drug development Structure, mechanism and regulation of pyruvate carboxylase Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and Dysfunction Metabolomics applied to the pancreatic islet Mechanisms of amino acid-stimulated insulin secretion in congenital hyperinsulinism Interaction between the Biotin Carboxyl Carrier Domain and the Biotin Carboxylase Domain in Pyruvate Carboxylase from Rhizobium etli Mitochondrial pyruvate transport: a historical perspective and future research directions Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: has it been overlooked?Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cell Beta-cell alpha-ketoglutarate hydroxylases may acutely participate in insulin secretion A role for G(z) in pancreatic islet beta-cell biology Enhanced rat beta-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathway Malic enzyme is present in mouse islets and modulates insulin secretion Suppression of the nuclear factor Eny2 increases insulin secretion in poorly functioning INS-1E insulinoma cells Metabolomics in the study of kidney diseases Characterization of the human pancreatic islet proteome by two-dimensional LC/MS/MS Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K mice Toward the Design of MR Agents for Imaging β-Cell Function.Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion Insulin secretion and insulin-producing tumors Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells.The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion.Regulation of insulin secretion: role of mitochondrial signalling.Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element A strategy for sensitive, large scale quantitative metabolomics Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.ß-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.MAFA controls genes implicated in insulin biosynthesis and secretion Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion.NMR-based stable isotope resolved metabolomics in systems biochemistry.Investigating the roles of mitochondrial and cytosolic malic enzyme in insulin secretion.

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13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

http://www.wikidata.org/entity/Q24530767

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2002 nî lūn-bûn

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2002 թուականի Մարտին հրատարակուած գիտական յօդուած

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2002 թվականի մարտին հրատարակված գիտական հոդված

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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Proceedings of the National Academy of Sciences of the United States of America

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13C NMR isotopomer analysis re ...... lated insulin secretion (GSIS)

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Christopher B Newgard

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Danhong Lu

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Mette V Jensen

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Piyu Zhao

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Shawn C Burgess

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P2860

Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells.

Separation of the glucose-stimulated cytoplasmic and mitochondrial NAD(P)H responses in pancreatic islet beta cells

Metabolic coupling factors in pancreatic beta-cell signal transduction.

Mutant methodology in the study of carbohydrate transport.

Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells.

Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion.

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

Heterogeneity in glucose sensitivity among pancreatic beta-cells is correlated to differences in glucose phosphorylation rather than glucose transport.

Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling.

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

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2708-2713

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4615152

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10.1073/PNAS.052005699

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5

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99

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Svetlana V Kamzolova

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2002-03-01T00:00:00Z

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11481648

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11880625

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122412

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