Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood. - Wikidata - wikimedia - TriplyDB

Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood.

Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood.

http://www.wikidata.org/entity/Q39964121

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Developmental Pathways Direct Pancreatic Cancer Initiation from Its Cellular Origin An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system Transcription factor regulation of pancreatic organogenesis, differentiation and maturation An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning.Suppression of Ptf1a activity induces acinar-to-endocrine conversion.Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.C. elegans twist gene expression in differentiated cell types is controlled by autoregulation through intron elements A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord.Next-generation sequencing identifies the Danforth's short tail mouse mutation as a retrotransposon insertion affecting Ptf1a expression.A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse.Dominant and context-specific control of endodermal organ allocation by Ptf1a.Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors.Assessing the pathological relevance of SPINK1 promoter variants.The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma Deconstructing pancreas developmental biology.GATA4 and GATA6 control mouse pancreas organogenesis.Neurogenin3 cooperates with Foxa2 to autoactivate its own expression.Early pancreatic islet fate and maturation is controlled through RBP-Jκ Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility.MIST1 and PTF1 Collaborate in Feed-forward Regulatory Loops that Maintain the Pancreatic Acinar Phenotype in Adult Mice.Molecular and cellular regulation of pancreatic acinar cell function.Gene regulatory networks governing pancreas development.Sox9 and programming of liver and pancreatic progenitors.Transcriptional control of mammalian pancreas organogenesis.Cellular reprogramming for pancreatic β-cell regeneration: clinical potential of small molecule control.Identification of a functional enhancer variant within the chronic pancreatitis-associated SPINK1 c.101A>G (p.Asn34Ser)-containing haplotype.The E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 targets pancreas transcription factor 1a for proteasomal degradation.MiR-18a regulates expression of the pancreatic transcription factor Ptf1a in pancreatic progenitor and acinar cells.Repression by PRDM13 is critical for generating precision in neuronal identity Epithelial dynamics of pancreatic branching morphogenesis.Regulating the dorsal neural tube expression of Ptf1a through a distal 3' enhancer.Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord.On the role of lateral stabilization during early patterning in the pancreas Specific transduction and labeling of pancreatic ducts by targeted recombinant viral infusion into mouse pancreatic ducts.Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A.Distinct enhancers of ptf1a mediate specification and expansion of ventral pancreas in zebrafish.

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P2860

Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood.

http://www.wikidata.org/entity/Q39964121

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

Transcriptional autoregulation ...... ing development and adulthood.

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Transcriptional autoregulation ...... ing development and adulthood.

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type

label

Transcriptional autoregulation ...... ing development and adulthood.

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Transcriptional autoregulation ...... ing development and adulthood.

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prefLabel

Transcriptional autoregulation ...... ing development and adulthood.

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Transcriptional autoregulation ...... ing development and adulthood.

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Molecular and Cellular Biology

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Transcriptional autoregulation ...... ing development and adulthood.

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David M Meredith

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Galvin H Swift

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Michael A Hale

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Raymond J Macdonald

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Toshihiko Masui

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P2860

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

Mutations in PTF1A cause pancreatic and cerebellar agenesis

PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.

The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

BLAT--the BLAST-like alignment tool

Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells

Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas

The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas

Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex

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10.1128/MCB.00549-08

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17

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28

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5245790

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18606784

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2519732

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