Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.
about
Membrane cholesterol regulates lysosome-plasma membrane fusion events and modulates Trypanosoma cruzi invasion of host cellsAn intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.Loss-of-function mutations in ABCA1 and enhanced β-cell secretory capacity in young adultsDifferential impact of statin on new-onset diabetes in different age groups: a population-based case-control study in women from an asian countryMembrane cholesterol removal changes mechanical properties of cells and induces secretion of a specific pool of lysosomes.Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell lineRosuvastatin and atorvastatin: comparative effects on glucose metabolism in non-diabetic patients with dyslipidaemia.Rosuvastatin Worsens Insulin Resistance in HIV-Infected Adults on Antiretroviral Therapy.bSUM: A bead-supported unilamellar membrane system facilitating unidirectional insertion of membrane proteins into giant vesicles.A scissors mechanism for stimulation of SNARE-mediated lipid mixing by cholesterolDo statins really cause diabetes? A meta-analysis of major randomized controlled clinical trials.Diabetogenic effect of statins: a double-edged sword?Cholesterol, regulated exocytosis and the physiological fusion machine.Do statins cause diabetes?Benefit-risk assessment of rosuvastatin in the treatment of atherosclerosis and related diseases.Cholesterol-enriched membrane rafts and insulin secretion.Lipid-lowering therapies, glucose control and incident diabetes: evidence, mechanisms and clinical implications.The good and bad effects of statins on insulin sensitivity and secretion.Statins and their increased risk of inducing diabetes.The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts.Incidence, Predictors, and Clinical Outcomes of New-Onset Diabetes Mellitus after Percutaneous Coronary Intervention with Drug-Eluting StentThe dynamic plasticity of insulin production in β-cells.High-density lipoprotein function in regulating insulin secretion: possible relevance to metabolic syndromeThe long-term effect of statins on the risk of new-onset diabetes mellitus in elderly Taiwanese patients with hypertension and dyslipidaemia: a retrospective longitudinal cohort study.Excess cholesterol inhibits glucose-stimulated fusion pore dynamics in insulin exocytosis.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Reduced membrane cholesterol limits pulmonary endothelial Ca2+ entry after chronic hypoxia.Statin therapy is associated with the development of new-onset diabetes after transplantation in liver recipients with high fasting plasma glucose levels.Control of Insulin Granule Formation and Function by the ABC Transporters ABCG1 and ABCA1 and by Oxysterol Binding Protein OSBP.Relationship between very low low-density lipoprotein cholesterol concentrations not due to statin therapy and risk of type 2 diabetes: A US-based cross-sectional observational study using electronic health records
P2860
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P2860
Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Inhibition of cholesterol bios ...... tion in pancreatic beta-cells.
@en
Inhibition of cholesterol bios ...... tion in pancreatic beta-cells.
@nl
type
label
Inhibition of cholesterol bios ...... tion in pancreatic beta-cells.
@en
Inhibition of cholesterol bios ...... tion in pancreatic beta-cells.
@nl
prefLabel
Inhibition of cholesterol bios ...... tion in pancreatic beta-cells.
@en
Inhibition of cholesterol bios ...... tion in pancreatic beta-cells.
@nl
P2093
P356
P1433
P1476
Inhibition of cholesterol bios ...... tion in pancreatic beta-cells.
@en
P2093
Anton Mihic
Fuzhen Xia
Herbert Y Gaisano
Robert G Tsushima
Xiaodong Gao
P304
P356
10.1210/EN.2008-0161
P407
P577
2008-07-03T00:00:00Z