The tyrosine phosphorylation of Munc18c induces a switch in binding specificity from syntaxin 4 to Doc2beta.
about
Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c in vitroMunc18c depletion selectively impairs the sustained phase of insulin releasePositional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretionExocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4Doc2b enrichment enhances glucose homeostasis in mice via potentiation of insulin secretion and peripheral insulin sensitivityMunc18c: a controversial regulator of peripheral insulin action.Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosisStimulus-induced S-nitrosylation of Syntaxin 4 impacts insulin granule exocytosisDoc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet β-cellsGelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis.Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoformsDoc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivityDoc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent mannerMechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins.SNARE proteins underpin insulin-regulated GLUT4 traffic.Mapping insulin/GLUT4 circuitry.A proteolytic pathway that controls glucose uptake in fat and muscle.Studies of the regulated assembly of SNARE complexes in adipocytes.Exocytosis proteins as novel targets for diabetes prevention and/or remediation?Promoting Glucose Transporter-4 Vesicle Trafficking along Cytoskeletal Tracks: PAK-Ing Them Out.Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.Evidence for a conserved inhibitory binding mode between the membrane fusion assembly factors Munc18 and syntaxin in animals.Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function.Protecting functional β cells with a therapeutic peptide
P2860
Q28474414-3DB501F0-1C5F-4EE7-BDA9-F0179D8CBAEFQ28504638-CD3C0D83-FB4A-45B6-A069-A220F6A1A131Q28506444-04E54063-EF92-464F-9BF9-4E23FB65522AQ33728169-010184D3-79E7-4502-89E6-84FC24A653F4Q33747970-042DA211-BF4A-4D32-B485-34C2B5A073D3Q34620390-A25B3FC9-FEB4-468E-A851-03C58E8056FDQ34854424-F6A07FE0-5C49-4860-9404-9757C6AE1D37Q34963637-99692D9F-37F3-40DC-B983-D7E75840E182Q35565528-A7DBAE5D-C726-4061-A8A0-6E20F8858A7FQ35640692-03B7B15C-5B7D-4847-8811-DF0B454BEE66Q36122094-54F03B4A-90AB-4508-A06E-98A0108252CCQ36249741-9B2CCFF8-389F-41C3-90A1-0FC4B8443DDDQ36758428-E7B339F2-2F11-4C99-A91A-29208677FD1DQ37417286-CF1480A7-9AE3-4D87-9CE7-DEC826D9B7AAQ37827900-9669EF84-1B31-4F90-9932-71C52109C43AQ37852799-F0565C2E-BEEE-4D16-8807-987ED596C3CCQ38151511-8EE51568-5CE6-47C5-A2EA-4E72B45E758BQ38252302-C83D634D-3643-4931-8AAD-9515323BE509Q39207341-D63219C7-72AC-4A4A-8428-A0C7B33FF9CAQ47148579-7B722E43-2252-4BFE-A5B2-795DE00924BDQ47259015-5463F9A7-DD80-4195-B8B4-B06CF9ED197EQ47632016-C8BCE526-0F5E-44DA-B199-5606F4C08E07Q52319815-45487C70-7612-48DA-9031-EDC99FE502ECQ58127663-5C186F4A-DCCA-4B2F-92DD-E6E29916CB41
P2860
The tyrosine phosphorylation of Munc18c induces a switch in binding specificity from syntaxin 4 to Doc2beta.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
The tyrosine phosphorylation o ...... y from syntaxin 4 to Doc2beta.
@en
The tyrosine phosphorylation o ...... y from syntaxin 4 to Doc2beta.
@nl
type
label
The tyrosine phosphorylation o ...... y from syntaxin 4 to Doc2beta.
@en
The tyrosine phosphorylation o ...... y from syntaxin 4 to Doc2beta.
@nl
prefLabel
The tyrosine phosphorylation o ...... y from syntaxin 4 to Doc2beta.
@en
The tyrosine phosphorylation o ...... y from syntaxin 4 to Doc2beta.
@nl
P2093
P2860
P356
P1476
The tyrosine phosphorylation o ...... y from syntaxin 4 to Doc2beta.
@en
P2093
Debbie C Thurmond
Jenna L Jewell
Samy O Meroueh
Sara M Bennett
P2860
P304
21734-21746
P356
10.1074/JBC.M710445200
P407
P577
2008-06-09T00:00:00Z