Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia. - Wikidata - wikimedia - TriplyDB

Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia.

Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia.

http://www.wikidata.org/entity/Q39981349

about

An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.The ubiquitin-proteasomal system is critical for multiple myeloma: implications in drug discovery Fibroblast growth factor signaling in myofibroblasts differs from lipofibroblasts during alveolar septation in mice.Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling Intermolecular interactions of Sprouty proteins and their implications in development and disease.Identification of therapeutic targets for Parkinson's disease via bioinformatics analysis.FGFR3 targeting strategies for achondroplasia.Current Care and Investigational Therapies in Achondroplasia.The physical basis of FGFR3 response to fgf1 and fgf2.Cell adaptation to activated FGFR3 includes Sprouty4 up regulation to inhibit the receptor-mediated ERKs activation from the endoplasmic reticulum.Fibroblast growth factor receptor 3 (FGFR3) is a strong heat shock protein 90 (Hsp90) client: implications for therapeutic manipulation.Statin treatment rescues FGFR3 skeletal dysplasia phenotypes.FGFR3 biology and skeletal disease.

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Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia.

http://www.wikidata.org/entity/Q39981349

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

Sprouty 2 disturbs FGFR3 degra ...... form of human achondroplasia.

@en

Sprouty 2 disturbs FGFR3 degra ...... form of human achondroplasia.

@nl

type

label

Sprouty 2 disturbs FGFR3 degra ...... form of human achondroplasia.

@en

Sprouty 2 disturbs FGFR3 degra ...... form of human achondroplasia.

@nl

prefLabel

Sprouty 2 disturbs FGFR3 degra ...... form of human achondroplasia.

@en

Sprouty 2 disturbs FGFR3 degra ...... form of human achondroplasia.

@nl

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J.CELLSIG.2008.04.001

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Cellular Signalling

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Sprouty 2 disturbs FGFR3 degra ...... form of human achondroplasia.

@en

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Catherine R Degnin

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Changsheng Guo

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Deborah Krakow

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Gregory P Lunstrum

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Jeanie Bihlmaier

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Melanie B Laederich

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Paul Holden

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William A Horton

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Yoon-Jae Cho

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P2860

Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function

sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways

FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.

Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

Fibroblast growth factor receptor 3 mutations in achondroplasia and related forms of dwarfism

Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia

Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling

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1471-1477

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10.1016/J.CELLSIG.2008.04.001

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8

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18485666

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