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The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

http://www.wikidata.org/entity/Q40003738

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SIRT2 as a Therapeutic Target for Age-Related Disorders Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates.Endothelial Barrier and Its Abnormalities in Cardiovascular Disease HDAC signaling in neuronal development and axon regeneration Community structure analysis of transcriptional networks reveals distinct molecular pathways for early- and late-onset temporal lobe epilepsy with childhood febrile seizures Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2.Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration.High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarction.Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development.Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration.Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease.SIRT2 plays a key role in both cell cycle regulation and cell survival of BV2 microglia.At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology.Sirtuin catalysis and regulation Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells.Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis.Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects.Post-translational modifications of tubulin: pathways to functional diversity of microtubules.Differential expression of sirtuins in the aging rat brain ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53 Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7 Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2).Protein deacetylases and axonal regeneration.Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors SIRT2 plays a significant role in maintaining the survival and energy metabolism of PIEC endothelial cells.Structural prediction of the interaction of the tumor suppressor p27KIP1 with cyclin A/CDK2 identifies a novel catalytically relevant determinant Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies.Deacetylation of H4-K16Ac and heterochromatin assembly in senescence.

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P2860

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

http://www.wikidata.org/entity/Q40003738

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

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type

label

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

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prefLabel

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

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Journal of Cell Biology

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The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

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P2093

Alexandra Wolf

http://www.w3.org/2001/XMLSchema#string

Bernd Knöll

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Britta Jedamzik

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Edwin Lasonder

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Elisabeth Kremmer

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Juliane Lüscher-Firzlaff

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Kai Harting

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Richard Lilischkis

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Ruwin Pandithage

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P2860

PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

HDAC6 is a microtubule-associated deacetylase

Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle

Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation

Regulation of the transcription factor FOXM1c by Cyclin E/CDK2

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis

A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library

P304

915-929

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scholarly article

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10.1083/JCB.200707126

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5

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180

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Jörg Vervoorts

Bernhard Lüscher

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2008-03-01T00:00:00Z

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5520471

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18332217

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2265402

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