Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1.
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Integrating TRPV1 Receptor Function with Capsaicin PsychophysicsExploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screeningtmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans.Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist.Polysulfide evokes acute pain through the activation of nociceptive TRPA1 in mouse sensory neurons.Molecular cloning and functional characterization of Xenopus tropicalis frog transient receptor potential vanilloid 1 reveal its functional evolution for heat, acid, and capsaicin sensitivities in terrestrial vertebrates.Lack of transient receptor potential vanilloid 1 channel modulates the development of neurogenic bladder dysfunction induced by cross-sensitization in afferent pathwaysAn external sodium ion binding site controls allosteric gating in TRPV1 channelsInvolvement of TRPA1 activation in acute pain induced by cadmium in miceImpact of autologous blood injections in treatment of mid-portion Achilles tendinopathy: double blind randomised controlled trial.Proton inhibition of unitary currents of vanilloid receptors.The fundamental unit of pain is the cell.Divalent cations activate TRPV1 through promoting conformational change of the extracellular region.Divalent cations potentiate TRPV1 channel by lowering the heat activation thresholdScreening TRPV1 antagonists for the treatment of pain: lessons learned over a decade.Acidic tumor microenvironment in human melanoma.Inflammatory acidic pH enhances hydrogen sulfide-induced transient receptor potential ankyrin 1 activation in RIN-14B cells.GPR55-dependent and -independent ion signalling in response to lysophosphatidylinositol in endothelial cells.Colonic inflammation up-regulates voltage-gated sodium channels in bladder sensory neurons via activation of peripheral transient potential vanilloid 1 receptors.Acidic extracellular microenvironment and cancer.Identification of molecular determinants for a potent mammalian TRPA1 antagonist by utilizing species differences.Possible involvement of transient receptor potential ankyrin 1 in Ca2+ signaling via T-type Ca2+ channel in mouse sensory neurons.
P2860
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P2860
Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1.
description
2008 nî lūn-bûn
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2008年の論文
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2008年論文
@yue
2008年論文
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2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
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2008年论文
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2008年论文
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name
Novel gating and sensitizing m ...... al protonation sites on TRPV1.
@en
type
label
Novel gating and sensitizing m ...... al protonation sites on TRPV1.
@en
prefLabel
Novel gating and sensitizing m ...... al protonation sites on TRPV1.
@en
P2093
P2860
P356
P1476
Novel gating and sensitizing m ...... al protonation sites on TRPV1.
@en
P2093
Shigeo Ito
Toshiaki Imagawa
Toshio Ohta
P2860
P304
P356
10.1074/JBC.M709377200
P407
P577
2008-01-29T00:00:00Z