17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer.
about
Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol productionCreation of a free, Internet-accessible database: the Multiple Target Ligand DatabaseSpecies used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1Hydroxybenzothiazoles as new nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1)Novel hydroxysteroid (17beta) dehydrogenase 1 inhibitors reverse estrogen-induced endometrial hyperplasia in transgenic miceEstrogen and androgen-converting enzymes 17β-hydroxysteroid dehydrogenase and their involvement in cancer: with a special focus on 17β-hydroxysteroid dehydrogenase type 1, 2, and breast cancer.The Activity of SN33638, an Inhibitor of AKR1C3, on Testosterone and 17β-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast Cancer.The influence of bovine milk high or low in isoflavones on hepatic gene expression in mice.The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a phase I study.The Role of Androgens in Normal and Malignant Breast Tissue.Comparison of functional proteomic analyses of human breast cancer cell lines T47D and MCF7Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase: structure-function studies and inhibitor development.Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation.Overexpression of 17β-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death.Genetic polymorphisms and obesity influence estradiol decline during the menopause.Identification of Hydroxysteroid (17β) dehydrogenase type 12 (HSD17B12) as a CD8+ T-cell-defined human tumor antigen of human carcinomasSynergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer.Endocrine resistance in breast cancer--An overview and update.The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer.Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression.Cysteine-10 on 17 β -Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals.17beta-Hydroxysteroid dehydrogenase inhibitors: a patent review.Regulation of 17β-hydroxysteroid dehydrogenases in cancer: regulating steroid receptor at pre-receptor stage.Oestrogen and colorectal cancer: mechanisms and controversies.Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol.Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells.Target deletion of the bifunctional type 12 17β-hydroxysteroid dehydrogenase in mice results in reduction of androgen and estrogen levels in heterozygotes and embryonic lethality in homozygotes.Blocking 17β-hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach.MTLD, a Database of Multiple Target Ligands, the Updated Version.A validated and rapid high-performance liquid chromatography method for the quantification of conversion of radio-labelled sex steroids.Cytosolic and Transmembrane Protein Extraction Methods of Breast and Ovarian Cancer Cells: A Comparative Study
P2860
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P2860
17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
17beta-hydroxysteroid dehydrog ...... rmone-dependent breast cancer.
@en
type
label
17beta-hydroxysteroid dehydrog ...... rmone-dependent breast cancer.
@en
prefLabel
17beta-hydroxysteroid dehydrog ...... rmone-dependent breast cancer.
@en
P2093
P2860
P356
P1476
17beta-hydroxysteroid dehydrog ...... ormone-dependent breast cancer
@en
P2093
Atul Purohit
Barry V L Potter
Gillian M Allan
Harshani R Lawrence
Helena J Tutill
Joanna M Day
Michael F C Parsons
Michael J Reed
Nigel Vicker
Simon P Newman
P2860
P304
P356
10.1002/IJC.23350
P50
P577
2008-05-01T00:00:00Z