Orai1 subunit stoichiometry of the mammalian CRAC channel pore.
about
Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetrySTIM and Orai1 Variants in Store-Operated Calcium EntryStructural aspects of calcium-release activated calcium channel functionUsing concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptorsPermeation, selectivity and gating in store-operated CRAC channelsOrai3--the 'exceptional' Orai?The STIM1/Orai signaling machineryMolecular regulation of CRAC channels and their role in lymphocyte functionStore-operated Orai channels: structure and functionCalcium influx pathways in breast cancer: opportunities for pharmacological interventionCrystal Structure of the Calcium Release-Activated Calcium Channel OraiCalcium Dyshomeostasis in Tubular Aggregate MyopathyDiseases caused by mutations in ORAI1 and STIM1Animal Ca2+ release-activated Ca2+ (CRAC) channels appear to be homologous to and derived from the ubiquitous cation diffusion facilitators.Hair loss and defective T- and B-cell function in mice lacking ORAI1STIMulating store-operated Ca(2+) entry.Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cellsα-SNAP regulates dynamic, on-site assembly and calcium selectivity of Orai1 channels.Tetrameric Orai1 is a teardrop-shaped molecule with a long, tapered cytoplasmic domainThe intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels.Pore architecture of the ORAI1 store-operated calcium channel.The serine-threonine phosphatase calcineurin is a regulator of endothelial store-operated calcium entryMolecular basis of calcium signaling in lymphocytes: STIM and ORAICalcium signaling in immune cells.CRAC channelopathies.Regulation of Ca2+ signaling with particular focus on mast cells.A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid.Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borateCalcium signaling in lymphocytesActivation and regulation of store-operated calcium entry.Molecular biophysics of Orai store-operated Ca2+ channels.STIM and Orai: the long-awaited constituents of store-operated calcium entryStoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1).Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunitsMutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states.STIM1L traps and gates Orai1 channels without remodeling the cortical ERStore-operated calcium channels: new perspectives on mechanism and function.STIM and Orai proteins and the non-capacitative ARC channels.
P2860
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P2860
Orai1 subunit stoichiometry of the mammalian CRAC channel pore.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Orai1 subunit stoichiometry of the mammalian CRAC channel pore.
@en
type
label
Orai1 subunit stoichiometry of the mammalian CRAC channel pore.
@en
prefLabel
Orai1 subunit stoichiometry of the mammalian CRAC channel pore.
@en
P2860
P1476
Orai1 subunit stoichiometry of the mammalian CRAC channel pore
@en
P2093
Jill L Thompson
Trevor J Shuttleworth
P2860
P304
P356
10.1113/JPHYSIOL.2007.147249
P407
P577
2007-11-15T00:00:00Z