Cyclic GMP accumulation causes degeneration of photoreceptor cells: simulation of an inherited disease.
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Mutation spectrum of the gene encoding the beta subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosaFunctional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in miceCharacterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cellsReview: the history and role of naturally occurring mouse models with Pde6b mutationsDifferential proteomic analysis of the mouse retina: the induction of crystallin proteins by retinal degeneration in the rd1 mouse.Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements.Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors.Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse.shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosaA truncated form of rod photoreceptor PDE6 β-subunit causes autosomal dominant congenital stationary night blindness by interfering with the inhibitory activity of the γ-subunit.Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors.Requirement for cGMP in nerve cell death caused by glutathione depletion.Calcium effects on frog retinal cyclic guanosine 3', 5'-monophosphate levels and their light-initiated rate of decayRole of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration.Endogenous nitric oxide: physiology, pathology and clinical relevance.In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function.A novel mutation and phenotypes in phosphodiesterase 6 deficiency.Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q).The retinal cGMP phosphodiesterase gamma-subunit - a chameleonAIPL1, A protein linked to blindness, is essential for the stability of enzymes mediating cGMP metabolism in cone photoreceptor cells.A current practice for predicting ocular toxicity of systemically delivered drugs.Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse.A review of the role of cyclic GMP in neurological mutants with photoreceptor dysplasia.Biological effects of light on proteins: enzyme activity modulation.Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms.Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an american ophthalmological society thesis).Criteria for development of animal models of diseases of the eye.Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium.Aberrant expression of c-Fos accompanies photoreceptor cell death in the rd mouse.Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration.Next-generation sequencing targeted disease panel in rod-cone retinal dystrophies in Māori and Polynesian reveals novel changes and a common founder mutation.Targeted disruption of Müller cell metabolism induces photoreceptor dysmorphogenesis.Müller glial cells induce stem cell properties in retinal progenitors in vitro and promote their further differentiation into photoreceptors.Regulation of adenylyl cyclase in LTP
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P2860
Cyclic GMP accumulation causes degeneration of photoreceptor cells: simulation of an inherited disease.
description
1977 nî lūn-bûn
@nan
1977年の論文
@ja
1977年学术文章
@wuu
1977年学术文章
@zh-cn
1977年学术文章
@zh-hans
1977年学术文章
@zh-my
1977年学术文章
@zh-sg
1977年學術文章
@yue
1977年學術文章
@zh
1977年學術文章
@zh-hant
name
Cyclic GMP accumulation causes ...... ation of an inherited disease.
@en
type
label
Cyclic GMP accumulation causes ...... ation of an inherited disease.
@en
prefLabel
Cyclic GMP accumulation causes ...... ation of an inherited disease.
@en
P2093
P356
P1433
P1476
Cyclic GMP accumulation causes ...... ation of an inherited disease.
@en
P2093
Hollyfield JG
Rayborn ME
P304
P356
10.1126/SCIENCE.193183
P407
P577
1977-05-01T00:00:00Z