Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors.
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Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytesIn Search of Enzymes with a Role in 3', 5'-Cyclic Guanosine Monophosphate Metabolism in PlantsStructural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunitPhosphodiesterase 6C, cGMP-specific cone alpha'.Probing the catalytic sites and activation mechanism of photoreceptor phosphodiesterase using radiolabeled phosphodiesterase inhibitorsPhosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin.Early alterations in mitochondrial reserve capacity; a means to predict subsequent photoreceptor cell death.Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.Infliximab reduces Zaprinast-induced retinal degeneration in cultures of porcine retina.cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal ExplantsIdentification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.Chronic sildenafil in men with diabetes and erectile dysfunction.Phosphodiesterase 5 inhibitors augment UT-15C-stimulated ATP release from erythrocytes of humans with pulmonary arterial hypertensionInhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retinaChronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily.Can Cyclic Nucleotide Phosphodiesterase Inhibitors Be Drugs for Parkinson's Disease?Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptorsRetinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms.Mitochondria Maintain Distinct Ca2+ Pools in Cone Photoreceptors.Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP effluxPDE5 Inhibitors as Potential Tools in the Treatment of Cystic Fibrosis.Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.Phosphodiesterase Inhibitors Sildenafil and Vardenafil Reduce Zebrafish Rod Photoreceptor Outer Segment Shedding.Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development.Vinpocetine modulates metabolic activity and function during retinal ischemia.Visual impairment with possible macular changes after a high dose of sildenafil in a healthy young woman.Xanthine scaffold: scope and potential in drug development
P2860
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P2860
Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors.
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Efficacy and selectivity of ph ...... E6) in retinal photoreceptors.
@ast
Efficacy and selectivity of ph ...... E6) in retinal photoreceptors.
@en
Efficacy and selectivity of ph ...... hotoreceptor phosphodiesterase
@nl
type
label
Efficacy and selectivity of ph ...... E6) in retinal photoreceptors.
@ast
Efficacy and selectivity of ph ...... E6) in retinal photoreceptors.
@en
Efficacy and selectivity of ph ...... hotoreceptor phosphodiesterase
@nl
prefLabel
Efficacy and selectivity of ph ...... E6) in retinal photoreceptors.
@ast
Efficacy and selectivity of ph ...... E6) in retinal photoreceptors.
@en
Efficacy and selectivity of ph ...... hotoreceptor phosphodiesterase
@nl
P2860
P356
P1476
Efficacy and selectivity of ph ...... DE6) in retinal photoreceptors
@en
P2093
Xiujun Zhang
P2860
P304
P356
10.1167/IOVS.05-0257
P407
P50
P577
2005-09-01T00:00:00Z