A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal melanoma.
about
Exploiting tumor epigenetics to improve oncolytic virotherapyExpression regulation of major histocompatibility complex class I and class II encoding genesOrchestrating epigenetic roles targeting ocular tumorsHistone Modifications, Modifiers and Readers in Melanoma Resistance to Targeted and Immune TherapyTargeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genesCancer Cells Hijack PRC2 to Modify Multiple Cytokine PathwaysPolycomb target genes are silenced in multiple myeloma.Role of Epigenetics in Uveal MelanomaLack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes.Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitorsDysregulated recruitment of the histone methyltransferase EZH2 to the class II transactivator (CIITA) promoter IV in breast cancer cells.Dynamic patterns of histone lysine methylation in the developing retina.CIITA is silenced by epigenetic mechanisms that prevent the recruitment of transactivating factors in rhabdomyosarcoma cells.Upregulation of HLA Expression in Primary Uveal Melanoma by Infiltrating LeukocytesPU.1 binds to a distal regulatory element that is necessary for B cell-specific expression of CIITA.PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma.Role of EZH2 histone methyltrasferase in melanoma progression and metastasisSomatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in MelanomaSkewed expression of the genes encoding epigenetic modifiers in high-risk uveal melanoma.Influence of immune privilege on ocular tumor development.EZH2: an emerging role in melanoma biology and strategies for targeted therapy.ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cellsGenetic and epigenetic control of the major histocompatibility complex class Ib gene HLA-G in trophoblast cell lines.IFN-γ Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages.Histone deacetylase inhibitors suppress immune activation in primary mouse microglia.
P2860
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P2860
A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal melanoma.
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年學術文章
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2007年學術文章
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2007年學術文章
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name
A role for EZH2 in silencing o ...... anscription in uveal melanoma.
@en
type
label
A role for EZH2 in silencing o ...... anscription in uveal melanoma.
@en
prefLabel
A role for EZH2 in silencing o ...... anscription in uveal melanoma.
@en
P2093
P1476
A role for EZH2 in silencing o ...... ranscription in uveal melanoma
@en
P2093
Erik Schooten
Louis Wilson
Marja C J A Van Eggermond
Marloes W T Bergevoet
Martine J Jager
Peter J F Snijders
Tjadine M Holling
P304
P356
10.4049/JIMMUNOL.179.8.5317
P407
P577
2007-10-01T00:00:00Z