about
Impaired neutrophil migration and phagocytosis in IRAK-4 deficiencyDisease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration.Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy.WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts.Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin.Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: modulatory role of regulatory B cellsFunctional gap junctions accumulate at the immunological synapse and contribute to T cell activationB cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1.Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiencyPhosphorylation of WASp is a key regulator of activity and stability in vivo.Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activationRecent advances in the understanding of genetic defects of neutrophil number and function.Stable gene transfer to muscle using non-integrating lentiviral vectors.Brain-derived human immunodeficiency virus-1 Tat exerts differential effects on LTR transactivation and neuroimmune activation.Nonintegrating lentivector vaccines stimulate prolonged T-cell and antibody responses and are effective in tumor therapy.Migratory and antigen presentation functions of IFN-producing killer dendritic cells.Genetic variants associated with neutrophil function in aggressive periodontitis and healthy controls.NOD mice have a severely impaired ability to recruit leukocytes into sites of inflammation.A partial down-regulation of WASP is sufficient to inhibit podosome formation in dendritic cells.CCL20 neutralization by a monoclonal antibody in healthy subjects selectively inhibits recruitment of CCR6+ cells in an experimental suction blister.Diabetes-prone NOD mice show an expanded subpopulation of mature circulating monocytes, which preferentially develop into macrophage-like cells in vitro.Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapseDendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapseCytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell primingImpaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cellsAn increased MRP8/14 expression and adhesion, but a decreased migration towards proinflammatory chemokines of type 1 diabetes monocytesEvidence for an enhanced adhesion of DC to fibronectin and a role of CCL19 and CCL21 in the accumulation of DC around the pre-diabetic islets in NOD miceCells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell culturesImmune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Gerben Bouma
@ast
Gerben Bouma
@en
Gerben Bouma
@es
Gerben Bouma
@sl
type
label
Gerben Bouma
@ast
Gerben Bouma
@en
Gerben Bouma
@es
Gerben Bouma
@sl
prefLabel
Gerben Bouma
@ast
Gerben Bouma
@en
Gerben Bouma
@es
Gerben Bouma
@sl
P108
P106
P1153
7006134013
P21
P31
P496
0000-0002-1465-9178
P569
2000-01-01T00:00:00Z