Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes.
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Novel pyrazolo[3,4-d]pyrimidine nucleoside analog with broad-spectrum antiviral activityDeoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivoIncreased incorporation of adenosine into adenine nucleotide pools in serum-deprived mammalian cellsConversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin.Mechanism of deoxyadenosine-induced catabolism of adenine ribonucleotides in adenosine deaminase-inhibited human T lymphoblastoid cellsPhenotypic variation in the response to the human immunodeficiency virus among derivatives of the CEM T and WIL-2 B cell linesResistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation.Proposed explanation for S-adenosylhomocysteine hydrolase deficiency in purine nucleoside phosphorylase and hypoxanthine-guanine phosphoribosyltransferase-deficient patientsIn vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients.In vitro of adenosine on lymphocytes and erythrocytes from horses with combined immunodeficiency.S-adenosylhomocysteine toxicity in normal and adenosine kinase-deficient lymphoblasts of human origin.Glial cells metabolically cooperate: a potential requirement for gene replacement therapy.The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene.Metabolomics analysis of soy hydrolysates for the identification of productivity markers of mammalian cells for manufacturing therapeutic proteins.Erythrocyte disorders of purine and pyrimidine metabolism.Amidophosphoribosyltransferase limits the rate of cell growth-linked de novo purine biosynthesis in the presence of constant capacity of salvage purine biosynthesis.Adenosine selectively inhibits labeling of chromosomal RNA, especially hnRNA, probably by acting at or near the site of chain initiation.Adenine attenuates lipopolysaccharide-induced inflammatory reactions.
P2860
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P2860
Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes.
description
1977 nî lūn-bûn
@nan
1977年の論文
@ja
1977年論文
@yue
1977年論文
@zh-hant
1977年論文
@zh-hk
1977年論文
@zh-mo
1977年論文
@zh-tw
1977年论文
@wuu
1977年论文
@zh
1977年论文
@zh-cn
name
Adenine and adenosine are toxi ...... ive in purine salvage enzymes.
@en
type
label
Adenine and adenosine are toxi ...... ive in purine salvage enzymes.
@en
prefLabel
Adenine and adenosine are toxi ...... ive in purine salvage enzymes.
@en
P2093
P356
P1433
P1476
Adenine and adenosine are toxi ...... ive in purine salvage enzymes.
@en
P2093
Hershfield MS
Seegmiller JE
P304
P356
10.1126/SCIENCE.197600
P407
P577
1977-09-01T00:00:00Z