Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo - Wikidata - wikimedia - TriplyDB

Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo

Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo

http://www.wikidata.org/entity/Q28366064

about

Apoptosis induces efflux of the mitochondrial matrix enzyme deoxyguanosine kinase Induction of apoptosis by 2-chloro-2'deoxyadenosine (2-CdA) alone and in combination with other cytotoxic drugs: synergistic effects on normal and neoplastic lymphocytes by addition of doxorubicin and mitoxantrone Cladribine in the treatment of chronic lymphocytic leukemia.2'-Chlorodeoxyadenosine: evaluation of a novel predominantly lymphocyte selective agent in lymphoid malignancies.Cladribine tablets: in relapsing-remitting multiple sclerosis.Cladribine tablets: a potential new short-course annual treatment for relapsing multiple sclerosis.Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1 Characterization of the deoxycytidine kinase promoter in human lymphoblast cell lines Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy.Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes Cladribine: not just another purine analogue?The cladribine conundrum: deciphering the drug's mechanism of action.Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance.Effects of 2-chloroadenine substitution in DNA on restriction endonuclease cleavage reactions.Substrate cycles and drug resistance to 1-beta-D-arabinofuranosylcytosine (araC).Antileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine.Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase Cladribine for multiple sclerosis: review and current status.Cladribine Analogues via O⁶-(Benzotriazolyl) Derivatives of Guanine Nucleosides Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine Control of fluxes in metabolic networks.Cladribine in indolent non-Hodgkin's lymphoma.Cladribine in the treatment of hairy cell leukemia: initial and subsequent results.The treatment of chronic progressive multiple sclerosis with cladribine.Development of cladribine at Scripps for hairy cell leukemia and current results.Hairy cell leukemia: a 'hair-raising' update.Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity.Effects of 2-chloro-2'-deoxyadenosine on the cell cycle in the human leukemia EHEB cell line.Synthesis of 5-chloroformycin A, 5-chloro-2'-deoxyformycin A and certain related 5,7-disubstituted 3-beta-D-ribofuranosylpyrazolo[4,3-d] pyrimidines from formycin A.2-Chlorodeoxyadenosine in the treatment of hairy cell leukemia and chronic lymphocytic leukemia.2-Chlorodeoxyadenosine: a new nucleoside agent effective in the treatment of lymphoid malignancies.2-Chlorodeoxyadenosine in the treatment of hairy cell leukemia.On the phosphorylation of 2-chlorodeoxyadenosine (CdA) and its correlation with clinical response in leukemia treatment.Selective uptake of toxic nucleoside (125IUdR) by resistant cancer.2 chlorodeoxyadenosine activity and cross resistance patterns in primary cultures of human hematologic neoplasms.2-Chloro-2'-deoxyadenosine monophosphate residues in DNA enhance susceptibility to 3'-->5' exonucleases.Cladribine inhibits a diltiazem-induced increase in red blood cell purine nucleotide concentrations in a zebrafish model.Exposure-disease continuum for 2-chloro-2'-deoxyadenosine, a prototype ocular teratogen. 1. Dose-response analysis.Treatment of children with Langerhans cell histiocytosis with 2-chlorodeoxyadenosine.Halogenated 7-deazapurine nucleosides: stereoselective synthesis and conformation of 2'-deoxy-2'-fluoro-beta-D-arabinonucleosides.

P2860

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P2860

Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo

http://www.wikidata.org/entity/Q28366064

description

1980 nî lūn-bûn

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1980 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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1980 թվականի նոյեմբերին հրատարակված գիտական հոդված

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1980年の論文

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1980年論文

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1980年論文

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1980年論文

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1980年論文

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1980年論文

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1980年论文

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Deoxycytidine kinase-mediated ...... murine L1210 leukemia in vivo

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Proceedings of the National Academy of Sciences of the United States of America

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Deoxycytidine kinase-mediated ...... murine L1210 leukemia in vivo

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B Ullman

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P2860

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency

Regulation of mammalian deoxyribonucleotide biosynthesis by nucleotides as activators and inhibitors.

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).

Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells.

Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines

Biochemical basis for differential deoxyadenosine toxicity to T and B lymphoblasts: role for 5'-nucleotidase.

Adenine and adenosine are toxic to human lymphoblast mutants defective in purine salvage enzymes.

Deoxyadenosine metabolism and cytotoxicity in cultured mouse T lymphoma cells: a model for immunodeficiency disease.

Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine.

Treatment of acute lymphoblastic leukemia with 2'-deoxycoformycin: clinical and biochemical consequences of adenosine deaminase inhibition.

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