Statins reduce amyloid-beta production through inhibition of protein isoprenylation. - Wikidata - wikimedia - TriplyDB

Statins reduce amyloid-beta production through inhibition of protein isoprenylation.

Statins reduce amyloid-beta production through inhibition of protein isoprenylation.

http://www.wikidata.org/entity/Q40103529

about

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease Protein prenylation and synaptic plasticity: implications for Alzheimer's disease Cholesterol balance in prion diseases and Alzheimer's disease Roles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease: short- and long-term modification by non-genetic risk factors Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion Statins, risk of dementia, and cognitive function: secondary analysis of the ginkgo evaluation of memory study Possible modification of Alzheimer's disease by statins in midlife: interactions with genetic and non-genetic risk factors Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway.Cholesterol-modifying strategies for Alzheimer's disease.Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation.New directions in the treatment of normal tension glaucoma.Isoprenoids, small GTPases and Alzheimer's disease.Statins and neuroprotection: a prescription to move the field forward Role of vascular risk factors and vascular dysfunction in Alzheimer's disease.Increased RhoA prenylation in the loechrig (loe) mutant leads to progressive neurodegeneration Molecular mechanisms underlying the effects of statins in the central nervous system.Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis.Rab GTPase prenylation hierarchy and its potential role in choroideremia disease Clavulanic acid increases dopamine release in neuronal cells through a mechanism involving enhanced vesicle trafficking.Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease.Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations.Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.Plasma membrane cholesterol content affects nitric oxide diffusion dynamics and signaling The therapeutic effects of Rho-ROCK inhibitors on CNS disorders.Regulation of cerebral cholesterol metabolism in Alzheimer disease.Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers.Substrate specificity of gamma-secretase and other intramembrane proteases.Rab proteins and Rab-associated proteins: major actors in the mechanism of protein-trafficking disorders.Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients.Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately?Lovastatin inhibits amyloid precursor protein (APP) beta-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts.Evidence of endothelial dysfunction in the development of Alzheimer's disease: Is Alzheimer's a vascular disorder?Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.Current concepts in Alzheimer's disease: a multidisciplinary review.Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans.Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease.

P2860

Q24650450-F55CEAB5-1EF9-45A6-82AB-EBBBB21BC757 Q26774272-5CCACCD1-DFA3-4FE0-B936-0AADC7BF70F8 Q26777969-CB96FE81-8726-4DAF-95D0-8E6828A0610C Q26858942-6A68B570-8D8D-4066-AF81-866D3B266E29 Q27002948-6C9C8386-634D-44A7-975A-6E5F938AAE04 Q27022694-B4173F25-C98D-48A1-91CF-6B408FED43B7 Q28294279-355D04CE-0C3A-43F3-BB9F-E0DF555E824B Q30417962-06FDF5CB-55E0-4C12-9760-4F19BAE89309 Q30814231-68E0E70E-039D-4AC0-AEB6-F8BE688F5CF8 Q31814817-AA97C308-9EA4-401D-A094-E1189C7AACD7 Q33347051-77AB7CA0-CA4D-4971-AA2F-A1761616D7E7 Q33773451-9E4F04AF-5764-40C5-A294-AFE8DED961F0 Q33785942-5BF75CAE-AF05-47F1-BD6C-02EF6B71149B Q33915441-1F219849-C2B4-4392-BE6C-EC640D7DC30D Q34015831-4CC9CCCF-27C4-4E48-AAEE-D63E83FF5846 Q34055011-658C14F7-1CE0-4D14-BBCD-4B300AEB0E55 Q34412406-15C68308-DCA1-4B5E-968B-67CBCD672AC0 Q34685463-6D34CAA4-8BD0-4061-AA26-F182B063085C Q35063057-809AC208-F359-4B5C-818A-635A44E51DA6 Q35072549-1843259E-2790-4C58-B7DE-27FFC45E36B8 Q35374914-238EE829-B643-4A53-ACEA-294A61BB7655 Q35634151-4A0243BA-F932-4C40-B2CE-9DC21BFA5CB7 Q35642416-BD2890F5-E9E8-4CD2-962D-654734E8BD1A Q35873625-FC40484E-37D4-4E89-99B4-1DEA738929A7 Q36235102-FC35FDAD-A317-4EF1-91CD-D363EF86FAD8 Q36739578-C28AB04C-3149-46D2-817B-6BD1E4D5709F Q36818193-5C0F3208-D7E7-49E2-A4E1-AFD303A2265F Q36841850-119CD758-CFB9-4583-A5BA-CE1FA233CC47 Q36959256-E5D21DC8-6200-4ADD-A2CA-0438700EFFD3 Q37073568-2C3EA7B8-B004-4AC7-9491-2A7E1CC546AC Q37157313-980C8CB9-24FB-442E-9D8E-6E17DAE7C15C Q37187284-48CF67FC-B980-433C-BA8C-CDCB69F0B47E Q37198579-20A010D5-8509-42EF-8695-1CCBB1E98DA4 Q37254798-940044D6-33B9-41C4-86FA-E2F16D96B04B Q37285389-81CCA9F7-2D49-47A8-B161-BC3772755A88 Q37341916-612AB50D-67DC-4FD6-8041-99A5A108BB71 Q37360292-D279C76B-6F80-4C5E-A118-19DF20E1DEA9 Q37377515-29AE08AD-65A7-47C3-9E91-E6173C8A7191 Q37385784-13272DEE-6678-40DA-ACB7-3BBFA0D81C64 Q37388833-2066A4CE-6E53-4475-A8DA-84BBECBF3096

P2860

Statins reduce amyloid-beta production through inhibition of protein isoprenylation.

http://www.wikidata.org/entity/Q40103529

description

2007 nî lūn-bûn

@nan

2007年の論文

@ja

2007年学术文章

@wuu

2007年学术文章

@zh-cn

2007年学术文章

@zh-hans

2007年学术文章

@zh-my

2007年学术文章

@zh-sg

2007年學術文章

@yue

2007年學術文章

@zh

2007年學術文章

@zh-hant

name

Statins reduce amyloid-beta production through inhibition of protein isoprenylation.

@en

type

label

Statins reduce amyloid-beta production through inhibition of protein isoprenylation.

@en

prefLabel

Statins reduce amyloid-beta production through inhibition of protein isoprenylation.

@en

P1433

Q40103529-09333F8A-0DF1-4EDE-A600-0114AF68750A

P1476

Q40103529-1B8A836D-1B87-4DDF-9B50-CD716B452C49

P2093

Q40103529-549EBD4E-8751-4A37-B9CC-FB419587D386

Q40103529-7B41A963-455C-4353-A76C-500AB56F884F

Q40103529-BFB825AF-B1F1-48FE-849E-15E022B77B20

Q40103529-C1D7A069-C7E5-4D59-A471-D63E059F8091

P2860

Q40103529-043C7B98-8CDB-4B5D-8F3C-1EDDCC6CCDF5

Q40103529-0C13978E-ADC6-4DDD-B563-4329752352DE

Q40103529-0D27FFDB-CE38-44D2-A339-F79090C0A46B

Q40103529-0FA92444-2364-4CBD-B34E-059C7D2DE4C6

Q40103529-122C7143-3212-4ECD-91AB-727289DF3C47

Q40103529-2033CD62-86C6-4FDB-8C1B-12627E62AB45

Q40103529-2083750C-F273-4C72-938E-82E801E8F3EA

Q40103529-2A28137C-912F-4463-8641-4D7EAC453FDD

Q40103529-35894792-1F33-49E8-99B5-8A1036E47BB9

Q40103529-3DB3F2B9-FBED-4A48-A023-77CF65756950

P304

Q40103529-11385060-6AF3-4D66-B2D0-B9F2E83CDF5B

P31

Q40103529-3B9265FE-4DD5-44D9-9D3B-23C9E3A0E18A

P356

Q40103529-4E227C60-397D-4625-801B-526C0E5047E6

P407

Q40103529-0348EFF3-5C52-45F6-8635-821612496C09

P433

Q40103529-07639B5B-0FB7-4DC2-B4FC-F7783A5F9144

P478

Q40103529-A5D7E4AB-1A77-4261-9CD4-44C3D05C761B

P577

Q40103529-7E7543F3-FDBB-423D-ACA1-F6B8588AA80C

P698

Q40103529-1E1E0914-4A5D-4DC6-BED3-0158D78031A2

P356

P1433

Journal of Biological Chemistry

P1476

Statins reduce amyloid-beta production through inhibition of protein isoprenylation.

@en

P2093

Brandy L Wilkinson

http://www.w3.org/2001/XMLSchema#string

Gary Landreth

http://www.w3.org/2001/XMLSchema#string

Stephen M Ostrowski

http://www.w3.org/2001/XMLSchema#string

Todd E Golde

http://www.w3.org/2001/XMLSchema#string

P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Purification and cloning of amyloid precursor protein beta-secretase from human brain

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

Clostridium difficile toxins: mechanism of action and role in disease.

Amyloid plaque core protein in Alzheimer disease and Down syndrome

Pleiotropic effects of statins

Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

P304

26832-26844

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M702640200

http://www.w3.org/2001/XMLSchema#string

P407

P433

37

http://www.w3.org/2001/XMLSchema#string

P478

282

http://www.w3.org/2001/XMLSchema#string

P577

2007-07-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

17646164

http://www.w3.org/2001/XMLSchema#string