Statins reduce amyloid-beta production through inhibition of protein isoprenylation.
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Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's diseaseOvernutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative DiseasesThe roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer diseaseProtein prenylation and synaptic plasticity: implications for Alzheimer's diseaseCholesterol balance in prion diseases and Alzheimer's diseaseRoles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease: short- and long-term modification by non-genetic risk factorsStatins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretionStatins, risk of dementia, and cognitive function: secondary analysis of the ginkgo evaluation of memory studyPossible modification of Alzheimer's disease by statins in midlife: interactions with genetic and non-genetic risk factorsLigand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway.Cholesterol-modifying strategies for Alzheimer's disease.Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation.New directions in the treatment of normal tension glaucoma.Isoprenoids, small GTPases and Alzheimer's disease.Statins and neuroprotection: a prescription to move the field forwardRole of vascular risk factors and vascular dysfunction in Alzheimer's disease.Increased RhoA prenylation in the loechrig (loe) mutant leads to progressive neurodegenerationMolecular mechanisms underlying the effects of statins in the central nervous system.Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis.Rab GTPase prenylation hierarchy and its potential role in choroideremia diseaseClavulanic acid increases dopamine release in neuronal cells through a mechanism involving enhanced vesicle trafficking.Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease.Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations.Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through AutophagyStatins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.Plasma membrane cholesterol content affects nitric oxide diffusion dynamics and signalingThe therapeutic effects of Rho-ROCK inhibitors on CNS disorders.Regulation of cerebral cholesterol metabolism in Alzheimer disease.Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers.Substrate specificity of gamma-secretase and other intramembrane proteases.Rab proteins and Rab-associated proteins: major actors in the mechanism of protein-trafficking disorders.Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients.Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately?Lovastatin inhibits amyloid precursor protein (APP) beta-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts.Evidence of endothelial dysfunction in the development of Alzheimer's disease: Is Alzheimer's a vascular disorder?Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.Current concepts in Alzheimer's disease: a multidisciplinary review.Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans.Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease.
P2860
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P2860
Statins reduce amyloid-beta production through inhibition of protein isoprenylation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Statins reduce amyloid-beta production through inhibition of protein isoprenylation.
@en
type
label
Statins reduce amyloid-beta production through inhibition of protein isoprenylation.
@en
prefLabel
Statins reduce amyloid-beta production through inhibition of protein isoprenylation.
@en
P2093
P2860
P356
P1476
Statins reduce amyloid-beta production through inhibition of protein isoprenylation.
@en
P2093
Brandy L Wilkinson
Gary Landreth
Stephen M Ostrowski
Todd E Golde
P2860
P304
26832-26844
P356
10.1074/JBC.M702640200
P407
P577
2007-07-23T00:00:00Z