The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.
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The adeno-associated virus type 2 regulatory proteins rep78 and rep68 interact with the transcriptional coactivator PC4.Large-scale adeno-associated viral vector production using a herpesvirus-based system enables manufacturing for clinical studiesA viral assembly factor promotes AAV2 capsid formation in the nucleolusExpression of human herpesvirus 6B rep within infected cells and binding of its gene product to the TATA-binding protein in vitro and in vivo.The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication.Inhibition of herpes simplex virus type 1 replication by adeno-associated virus rep proteins depends on their combined DNA-binding and ATPase/helicase activities.Adeno-associated virus type 2 rep protein inhibits human papillomavirus type 16 E2 recruitment of the transcriptional coactivator p300.Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome.Human adeno-associated virus type 5 is only distantly related to other known primate helper-dependent parvoviruses.Conditional site-specific integration into human chromosome 19 by using a ligand-dependent chimeric adeno-associated virus/Rep protein.A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay.Adeno-associated virus sensitizes HeLa cell tumors to gamma rays.DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsidsA genetic screen identifies a cellular regulator of adeno-associated virus.How adeno-associated virus Rep78 protein arrests cells completely in S phaseHerpes simplex virus type 1/adeno-associated virus rep(+) hybrid amplicon vector improves the stability of transgene expression in human cells by site-specific integration.Recruitment of polymerase to herpes simplex virus type 1 replication foci in cells expressing mutant primase (UL52) proteins.Adeno-associated virus type 2 wild-type and vector-mediated genomic integration profiles of human diploid fibroblasts analyzed by third-generation PacBio DNA sequencing.The assembly-activating protein promotes capsid assembly of different adeno-associated virus serotypes.Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.A Comprehensive RNA Sequencing Analysis of the Adeno-Associated Virus (AAV) Type 2 Transcriptome Reveals Novel AAV Transcripts, Splice Variants, and Derived ProteinsLive covisualization of competing adeno-associated virus and herpes simplex virus type 1 DNA replication: molecular mechanisms of interaction.Analysis of recombinant adeno-associated virus packaging and requirements for rep and cap gene products.Encapsidation of adeno-associated virus type 2 Rep proteins in wild-type and recombinant progeny virions: Rep-mediated growth inhibition of primary human cellsComprehensive Small RNA-Seq of Adeno-Associated Virus (AAV)-Infected Human Cells Detects Patterns of Novel, Non-Coding AAV RNAs in the Absence of Cellular miRNA Regulation.Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome.Novel Mutant AAV2 Rep Proteins Support AAV2 Replication without Blocking HSV-1 Helpervirus ReplicationIdentification of a heparin-binding motif on adeno-associated virus type 2 capsidsCharacterization of cell lines that inducibly express the adeno-associated virus Rep proteinsAdeno-associated virus Rep protein inhibits human immunodeficiency virus type 1 production in human cells.Modification of some biological properties of HeLa cells containing adeno-associated virus DNA integrated into chromosome 17A Regulatory Element Near the 3' End of the Adeno-Associated Virus rep Gene Inhibits Adenovirus Replication in cis by Means of p40 Promoter-Associated Short Transcripts.Targeting the central nervous system with herpes simplex virus / Sleeping Beauty hybrid amplicon vectors.Differential contribution of adeno-associated virus type 2 Rep protein expression and nucleic acid elements to inhibition of adenoviral replication in cis and in trans.Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus.Impact of VP1-specific protein sequence motifs on adeno-associated virus type 2 intracellular trafficking and nuclear entry.Adeno-associated virus type 2 protein interactions: formation of pre-encapsidation complexesRep-dependent initiation of adeno-associated virus type 2 DNA replication by a herpes simplex virus type 1 replication complex in a reconstituted system.Kinetics and frequency of adeno-associated virus site-specific integration into human chromosome 19 monitored by quantitative real-time PCR.Packaging of human chromosome 19-specific adeno-associated virus (AAV) integration sites in AAV virions during AAV wild-type and recombinant AAV vector production.
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The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.
description
1990 nî lūn-bûn
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1990年学术文章
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name
The adeno-associated virus rep ...... rus-induced DNA amplification.
@en
type
label
The adeno-associated virus rep ...... rus-induced DNA amplification.
@en
prefLabel
The adeno-associated virus rep ...... rus-induced DNA amplification.
@en
P2093
P2860
P1433
P1476
The adeno-associated virus rep ...... rus-induced DNA amplification.
@en
P2093
P2860
P304
P407
P577
1990-06-01T00:00:00Z