Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis.
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MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicityProtein Folding and Mechanisms of ProteostasisMechanisms of islet amyloidosis toxicity in type 2 diabetesOn the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP PeptidesNatural history of β-cell adaptation and failure in type 2 diabetesChaperones ameliorate beta cell dysfunction associated with human islet amyloid polypeptide overexpressionThe UPS in diabetes and obesity.Molecular mechanisms of tungstate-induced pancreatic plasticity: a transcriptomics approach.An islet in distress: β cell failure in type 2 diabetes.Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation.Methylglyoxal alters the function and stability of critical components of the protein quality control.A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.Distinct internalization pathways of human amylin monomers and its cytotoxic oligomers in pancreatic cellsProteasome dysfunction mediates high glucose-induced apoptosis in rodent beta cells and human isletsConcentration-dependent transitions govern the subcellular localization of islet amyloid polypeptideIslet Amyloid Polypeptide: Structure, Function, and Pathophysiology.Exposure to Maternal Diabetes in Utero and DNA Methylation Patterns in the Offspring.Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity.Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells.Proteasome regulates turnover of toxic human amylin in pancreatic cells.Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stressStress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes.Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology.The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes.Downregulation of Sfrp5 promotes beta cell proliferation during obesity in the rat.AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1.Modulation of AβPP and GSK3β by Endoplasmic Reticulum Stress and Involvement in Alzheimer's Disease.Involvement of ATP-sensitive potassium (K(ATP)) channels in the loss of beta-cell function induced by human islet amyloid polypeptide.Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome.Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.Regulation of autophagy and ubiquitinated protein accumulation by bFGF promotes functional recovery and neural protection in a rat model of spinal cord injury.Amyloid-induced β-cell dysfunction and islet inflammation are ameliorated by 4-phenylbutyrate (PBA) treatment.RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity.The Receptor for Advanced Glycation Endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and Exploiting Common Ground for Novel Amyloidosis Therapies.Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy.Effects of renin-angiotensin system blockade on the islet morphology and function in rats with long-term high-fat diet.Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart.
P2860
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P2860
Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Impairment of the ubiquitin-pr ...... ancreatic beta-cell apoptosis.
@en
type
label
Impairment of the ubiquitin-pr ...... ancreatic beta-cell apoptosis.
@en
prefLabel
Impairment of the ubiquitin-pr ...... ancreatic beta-cell apoptosis.
@en
P2093
P50
P921
P356
P1433
P1476
Impairment of the ubiquitin-pr ...... ancreatic beta-cell apoptosis.
@en
P2093
Ramon Gomis
Sakari Knuutila
Sílvia Casas
P304
P356
10.2337/DB07-0178
P407
P577
2007-06-11T00:00:00Z