about
Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural ProductsStudies on Morinia: recognition of Morinia longiappendiculata sp. nov. as a new endophytic fungus, and a new circumscription of Morinia pestalozzioides.Current approaches to exploit actinomycetes as a source of novel natural products.Discovery of bacterial fatty acid synthase inhibitors from a Phoma species as antimicrobial agents using a new antisense-based strategy.Occurrence, distribution, dereplication and efficient discovery of thiazolyl peptides by sensitive-resistant pair screening.High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.Platensimycin is a selective FabF inhibitor with potent antibiotic properties.High-content screening of natural products reveals novel nuclear export inhibitors.Mitochondrial complex I inhibitors, acetogenins, induce HepG2 cell death through the induction of the complete apoptotic mitochondrial pathway.New antitumoral acetogenin 'Guanacone type' derivatives: isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone.Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustris.Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors.Semisynthesis of antitumoral acetogenins: SAR of functionalized alkyl-chain bis-tetrahydrofuranic acetogenins, specific inhibitors of mitochondrial complex I.Specific interactions of monotetrahydrofuranic annonaceous acetogenins as inhibitors of mitochondrial complex I.Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010).Sponge-derived Kocuria and Micrococcus spp. as sources of the new thiazolyl peptide antibiotic kocurin.Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput screening in myotonic dystrophy type 1.Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi.Bacterial diversity from benthic mats of Antarctic lakes as a source of new bioactive metabolites.Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.A yeast-based in vivo bioassay to screen for class I phosphatidylinositol 3-kinase specific inhibitors.Inhibitory effects on mitochondrial complex I of semisynthetic mono-tetrahydrofuran acetogenin derivatives.Distribution of the antifungal agents sordarins across filamentous fungi.Manipulating filamentous fungus chemical phenotypes by growth on nutritional arrays.The discovery of moriniafungin, a novel sordarin derivative produced by Morinia pestalozzioides.Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola.A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin.A method for the selection of production media for actinomycete strains based on their metabolite HPLC profiles.Cherimolin-1, new selective inhibitor of the first energy-coupling site of the NADH: ubiquinone oxidoreductase (complex I).Enantiospecific semisynthesis of (+)-almuheptolide-A, a novel natural heptolide inhibitor of the mammalian mitochondrial respiratory chain.Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I.Isolation and Structural Elucidation of Cyclic Tetrapeptides from Onychocola scleroticaChemical and Physical Modulation of Antibiotic Activity in Emericella SpeciesSynthesis of N-diisopropyl phosphoryl benzyl-tetrahydroisoquinoline, a new class of mitochondrial complexes I and III inhibitorsPolyalthidin: new prenylated benzopyran inhibitor of the mammalian mitochondrial respiratory chainNew evidence for the multiplicity of ubiquinone- and inhibitor-binding sites in the mitochondrial complex IA deficiency in respiratory complex I in heart mitochondria from vitamin A-deficient rats is counteracted by an increase in coenzyme QEpoxy-acetogenins and other polyketide epoxy derivatives as inhibitors of the mitochondrial respiratory chain complex I10-Oximeguanacone, the first nitrogenated acetogenin derivative found to be a potent inhibitor of mitochondrial complex IKinetic characterization of mitochondrial complex I inhibitors using annonaceous acetogenins
P50
Q28552116-4F431DF2-B845-4E05-87FD-9792D1ABFA06Q31081947-3138B772-471A-4ECF-A3B0-6F3330F9F49EQ33712859-F8A80E29-05E4-4207-A0F4-5D207B428D16Q34505218-70A07EED-BA07-4622-97E9-4DFB0F59F86CQ34784122-E76FAF52-C0E8-4EEA-B4B6-924E946DDB95Q35353325-F44C397D-6A3A-4246-9977-48C62E3CD6FCQ38468310-EDB9C833-4250-4680-964E-63701C79F753Q39094551-29CC1699-6900-47D3-94FE-8F07A188D0B0Q39238972-8988E83A-107A-4BBC-BDF5-4BEE86EF7FC2Q40136688-6A94B31F-D036-46A0-9C6E-B5513BE34521Q40254970-C569BDEC-603F-4740-86CC-8F85756F614CQ40359272-526FBFF4-7CEC-41D0-9D55-9204B3D77AD9Q40734164-2BE430A0-4028-467A-AAAD-C703E35DAF80Q40777644-9A63EE39-24DE-4C92-B71E-5D43AF83FC72Q41175502-9C85393A-4688-4265-AD19-C746144DF3ECQ41899611-38C0F442-7A5C-477D-8C37-7759278E9132Q41997886-A9EB07A6-FC94-4B6C-8B73-236ADF70870DQ42628355-093FAE1C-C5E1-42F3-BE38-00D9A0A64D9CQ43455587-B5CAEBA1-CB61-4691-8368-5924044B6361Q43552110-92BA0B8C-5EE6-4CAF-904E-6517CE3BAA94Q44160494-C4547746-A62A-4B9A-9C1E-5D6610C57E3CQ44638725-62EAE41D-6560-4942-85BB-2BF6DD35DA2BQ45032845-5A2CBD52-39DA-40DF-9B49-0B74E0A1F01EQ46041691-13212DCC-0D42-4BE6-B104-B7422B87AE8EQ46720130-28C65BF7-1DED-442A-9F3E-30DFC9FC424DQ46779901-02544626-F3B4-4BC1-B06E-E24F2FE9E0D2Q50260762-7D46C906-17A6-41E3-8A0A-A8AA73829020Q51823137-1209FDD8-2368-4A06-9E9B-3DE5155ACF83Q52560030-8E9823B5-08E8-4187-AD3C-7D410A5969BFQ53940676-EEE22D14-6643-4CF8-8C8B-35F76C019E2DQ58854251-2634A278-4E57-4973-8B07-8AD0C13864B0Q58854260-4FA027AE-A5DC-4DFD-A2FD-B496F6A35C2FQ58854318-E69B1B55-61B0-4D23-90C8-F70D2A660AA4Q60997879-10BB1F4B-E7AD-4E19-B479-A24C2D839526Q71751622-EEDDC799-6FB6-4491-9624-2C862311AE42Q73079892-506E7526-6B1B-4BAD-A736-8DC22E7FB972Q73326211-2218E21C-FB2F-4990-9E0F-6C432FA80682Q73920900-5F0ABEA9-BB2B-4E52-88BA-0087943FF0D7Q77171718-36165D3D-72B4-4A75-9286-F61B0160CFEEQ78171727-D577F19D-5E9A-4E8D-AF0E-A5A1767413E8
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
José R Tormo
@ast
José R Tormo
@en
José R Tormo
@es
José R Tormo
@sl
type
label
José R Tormo
@ast
José R Tormo
@en
José R Tormo
@es
José R Tormo
@sl
prefLabel
José R Tormo
@ast
José R Tormo
@en
José R Tormo
@es
José R Tormo
@sl
P1053
M-1044-2014
P106
P21
P2798
P31
P3829
P496
0000-0001-6984-2941