Platensimycin is a selective FabF inhibitor with potent antibiotic properties. - Wikidata - wikimedia - TriplyDB

Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

http://www.wikidata.org/entity/Q38468310

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Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases New approaches to filling the gap in tuberculosis drug discovery Efflux-mediated drug resistance in bacteria: an update Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties A Review on Platensimycin: A Selective FabF Inhibitor Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH)The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis Bacterial lipids: metabolism and membrane homeostasis X-Ray Crystal Structure of Mycobacterium tuberculosis β-Ketoacyl Acyl Carrier Protein Synthase II (mtKasB)Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase Type I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structure Structure-assisted discovery of an aminothiazole derivative as a lead molecule for inhibition of bacterial fatty-acid synthesis Structure of 3-oxoacyl-(acyl-carrier protein) synthase II fromThermus thermophilusHB8 Inhibition of the fungal fatty acid synthase type I multienzyme complex Crystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer Structural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis Structural insights into bacterial resistance to cerulenin Using modern tools to probe the structure-function relationship of fatty acid synthases Antibacterial targets in fatty acid biosynthesis Structural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestis High-throughput screening and sensitized bacteria identify an M. tuberculosis dihydrofolate reductase inhibitor with whole cell activity Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery Downregulation of yidC in Escherichia coli by antisense RNA expression results in sensitization to antibacterial essential oils eugenol and carvacrol A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis Hitting bacteria at the heart of the central dogma: sequence-specific inhibition Antibiotics May Trigger Mitochondrial Dysfunction Inducing Psychiatric Disorders Antibiotics for emerging pathogens Acyl carrier protein: structure-function relationships in a conserved multifunctional protein family.Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis.Bioprospecting microbial natural product libraries from the marine environment for drug discovery.Synthesis and antibacterial activity of monocyclic 3-carboxamide tetramic acids The highly conserved bacterial RNase YbeY is essential in Vibrio cholerae, playing a critical role in virulence, stress regulation, and RNA processing A mechanism-based aryl carrier protein/thiolation domain affinity probe.Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria?Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery.Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents.

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P2860

Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

http://www.wikidata.org/entity/Q38468310

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2006 nî lūn-bûn

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2006年の論文

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

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P2093

Andrew Galgoci

http://www.w3.org/2001/XMLSchema#string

Angela Basilio

http://www.w3.org/2001/XMLSchema#string

Bruce Michael

http://www.w3.org/2001/XMLSchema#string

Chaowei Zhang

http://www.w3.org/2001/XMLSchema#string

Charles Gill

http://www.w3.org/2001/XMLSchema#string

Dennis Schmatz

http://www.w3.org/2001/XMLSchema#string

Doris Cully

http://www.w3.org/2001/XMLSchema#string

Fernando Pelaez

http://www.w3.org/2001/XMLSchema#string

Francisca Vicente

http://www.w3.org/2001/XMLSchema#string

Gopalakrishnan Parthasarathy

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P2860

THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS

Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes

Discovery of FabH/FabF inhibitors from natural products.

Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism

Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery

The interpretation of protein structures: estimation of static accessibility

Structural and functional organization of the animal fatty acid synthase

The Claisen condensation in biology

Response of Bacillus subtilis to cerulenin and acquisition of resistance.

Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.

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358-361

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10.1038/NATURE04784

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7091

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441

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16710421

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