Physiologically based pharmacokinetic modeling: principles and applications.
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PKQuest: capillary permeability limitation and plasma protein binding - application to human inulin, dicloxacillin and ceftriaxone pharmacokineticsPKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol.Methods to identify and characterize developmental neurotoxicity for human health risk assessment. III: pharmacokinetic and pharmacodynamic considerations.Microfabricated mammalian organ systems and their integration into models of whole animals and humansIntegrating cellular metabolism into a multiscale whole-body modelA Pharmacokinetics-Neural Mass Model (PK-NMM) for the Simulation of EEG Activity during Propofol AnesthesiaA Physiologically Based Pharmacokinetic Model of Amiodarone and its Metabolite Desethylamiodarone in Rats: Pooled Analysis of Published Data.Blood flow rate in normal and tumor-bearing rats in conscious state, under urethane anesthesia, and during systemic hypothermia.Three-dimensional visualization of physiologically based kinetic model outputsMetabolism of novel anti-HIV agent 3-cyanomethyl-4-methyl-DCK by human liver microsomes and recombinant CYP enzymes.Kinetic aspects of drug disposition in the lungs.Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys.Pharmacokinetics of antiviral polyoxometalates in rats.Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes.An imaging-driven model for liposomal stability and circulation.Physiologically based pharmacokinetic model of amphotericin B disposition in rats following administration of deoxycholate formulation (Fungizone®): pooled analysis of published data.Pharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeysA systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes.Use of physiologically-based pharmacokinetic modeling to simulate the profiles of 3-hydroxybenzo(a)pyrene in workers exposed to polycyclic aromatic hydrocarbons.Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment.Pharmacokinetics of beta-L-2',3'-dideoxy-5-fluorocytidine in rhesus monkeysAlternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.Gaussian mixture model-based classification of dynamic contrast enhanced MRI data for identifying diverse tumor microenvironments: preliminary resultsScaling basic toxicokinetic parameters from rat to man.An approach to mechanism-based cancer risk assessment for formaldehydePrediction of the volume of distribution of a drug: which tissue-plasma partition coefficients are needed?Antiviral activity and pharmacokinetics of 1-(2,3-dideoxy-2-fluoro-beta-L-glyceropent-2-enofuranosyl)cytosine.Toxicokinetics and physiologically based toxicokinetics in toxicology and risk assessment.Pharmacokinetics of a water-soluble fullerene in rats.Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model.Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys.Molecular Design of Bisphosphonate-Modified Proteins for Efficient Bone Targeting In Vivo.Preclinical pharmacology and pharmacokinetics of the anti-hepatitis virus agent 2'-fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil in mice and ratsA physiologically based pharmacokinetic model of mitoxantrone in mice and scale-up to humans: a semi-mechanistic model incorporating DNA and protein binding.A Whole-Body Physiologically Based Pharmacokinetic Model of Gefitinib in Mice and Scale-Up to HumansHaemodynamic and transport barriers to the treatment of solid tumours.Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rats.Data-derived safety factors for the evaluation of food additives and environmental contaminants.Future directions for drug transporter modelling.Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation.
P2860
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P2860
Physiologically based pharmacokinetic modeling: principles and applications.
description
1983 nî lūn-bûn
@nan
1983年の論文
@ja
1983年学术文章
@wuu
1983年学术文章
@zh-cn
1983年学术文章
@zh-hans
1983年学术文章
@zh-my
1983年学术文章
@zh-sg
1983年學術文章
@yue
1983年學術文章
@zh
1983年學術文章
@zh-hant
name
Physiologically based pharmacokinetic modeling: principles and applications.
@en
type
label
Physiologically based pharmacokinetic modeling: principles and applications.
@en
prefLabel
Physiologically based pharmacokinetic modeling: principles and applications.
@en
P356
P1476
Physiologically based pharmacokinetic modeling: principles and applications.
@en
P2093
P304
P356
10.1002/JPS.2600721003
P407
P577
1983-10-01T00:00:00Z