A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis.
about
Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replicationClonogenic assay of type a influenza viruses reveals noninfectious cell-killing (apoptosis-inducing) particlesThe H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cellsHost-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 proteinInfluenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKRStructural basis for suppression of a host antiviral response by influenza A virusStructural basis for dsRNA recognition by NS1 protein of influenza A virusX-ray structures of NS1 effector domain mutantsStructural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 proteinStructure of the iSH2 domain of human phosphatidylinositol 3-kinase p85β subunit reveals conformational plasticity in the interhelical turn regionFunctions of the influenza A virus NS1 protein in antiviral defenseThe interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replicationDimer interface of the effector domain of non-structural protein 1 from influenza A virus: an interface with multiple functionsNuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein.SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation.A quantitative proteomic analysis of lung epithelial (A549) cells infected with 2009 pandemic influenza A virus using stable isotope labelling with amino acids in cell culture.Conserved features of the PB2 627 domain impact influenza virus polymerase function and replicationMutations associated with severity of the pandemic influenza A(H1N1)pdm09 in humans: a systematic review and meta-analysis of epidemiological evidence.Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses.Emerging antiviral targets for influenza A virus.The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathwaysMutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus.Structures of influenza A proteins and insights into antiviral drug targets.Genetic divergence of influenza A NS1 gene in pandemic 2009 H1N1 isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemicsThe pathogenesis of influenza virus infections: the contributions of virus and host factorsThe influenza virus NS1 protein as a therapeutic target.Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1.Apoptosis, cytokine and chemokine induction by non-structural 1 (NS1) proteins encoded by different influenza subtypesIsolation and mutation trend analysis of influenza A virus subtype H9N2 in Egypt.Novel inhibitor of influenza non-structural protein 1 blocks multi-cycle replication in an RNase L-dependent manner.Novel influenza virus NS1 antagonists block replication and restore innate immune function.Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis.Detection of mammalian virulence determinants in highly pathogenic avian influenza H5N1 viruses: multivariate analysis of published data.Prediction of protein-protein interaction sites using an ensemble method.Immunization with live attenuated influenza viruses that express altered NS1 proteins results in potent and protective memory CD8+ T-cell responsesThe NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIVThe HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets.Species-specific contribution of the four C-terminal amino acids of influenza A virus NS1 protein to virulence.Mechanisms of severe acute respiratory syndrome pathogenesis and innate immunomodulation.Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse.
P2860
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P2860
A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
A site on the influenza A viru ...... lation of viral RNA synthesis.
@en
type
label
A site on the influenza A viru ...... lation of viral RNA synthesis.
@en
prefLabel
A site on the influenza A viru ...... lation of viral RNA synthesis.
@en
P2093
P1433
P1476
A site on the influenza A viru ...... lation of viral RNA synthesis.
@en
P2093
Ganes C Sen
Ji-Young Min
Robert M Krug
Shoudong Li
P304
P356
10.1016/J.VIROL.2007.01.038
P407
P577
2007-02-22T00:00:00Z