Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo.
about
The structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding modePharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals.ABL-N-induced apoptosis in human breast cancer cells is partially mediated by c-Jun NH2-terminal kinase activationJG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin.Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II).Artemisia absinthium (AA): a novel potential complementary and alternative medicine for breast cancer.Berberis libanotica Ehrenb extract shows anti-neoplastic effects on prostate cancer stem/progenitor cells.Anti-proliferative and apoptosis-inducing effects of camptothecin-20(s)-O-(2-pyrazolyl-1)acetic ester in human breast tumor MCF-7 cells.Emergence of Chinese drug discovery research: impact of hit and lead identification.All-trans retinoic acid synergizes with topotecan to suppress AML cells via promoting RARα-mediated DNA damageCancer therapies utilizing the camptothecins: a review of the in vivo literatureTanshinone-1 induces tumor cell killing, enhanced by inhibition of secondary activation of signaling networks.Effects of crude extracts from medicinal herbs Rhazya stricta and Zingiber officinale on growth and proliferation of human brain cancer cell line in vitro.The pH-controlled nanoparticles size of polydopamine for anti-cancer drug delivery.An overview of quinoline as a privileged scaffold in cancer drug discovery.MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation.Calculated Log D Is Inversely Correlated With Select Camptothecin Clearance and Efficacy in Colon Cancer Xenografts.Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells.Alkaloids isolated from natural herbs as the anticancer agents.Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer?Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells.
P2860
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P2860
Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Chimmitecan, a novel 9-substit ...... profiles in vitro and in vivo.
@en
type
label
Chimmitecan, a novel 9-substit ...... profiles in vitro and in vivo.
@en
prefLabel
Chimmitecan, a novel 9-substit ...... profiles in vitro and in vivo.
@en
P2093
P1476
Chimmitecan, a novel 9-substit ...... profiles in vitro and in vivo.
@en
P2093
Heyong Gao
Hongwu Shen
Hualiang Jiang
Jian Zhang
Liping Lin
Xiongwen Zhang
P304
P356
10.1158/1078-0432.CCR-06-1277
P407
P577
2007-02-07T00:00:00Z