The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.
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Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolismAMPK: a cellular metabolic and redox sensor. A minireviewThe epidermal growth factor receptor variant III (EGFRvIII): where wild things are alteredMechanisms of amino acid-stimulated insulin secretion in congenital hyperinsulinismRegulatory roles for L-arginine in reducing white adipose tissueRole of AKT/mTORC1 pathway in pancreatic β-cell proliferationRecent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cellsCoordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cellsAblation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.Central exercise action increases the AMPK and mTOR response to leptinThe Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesBRole of phospholipase D1 in glucose-induced insulin secretion in pancreatic Beta cells.Leucine acts in the brain to suppress food intake but does not function as a physiological signal of low dietary protein.Targeted therapies of the LKB1/AMPK pathway for the treatment of insulin resistanceAMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gutLoss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.Leucine metabolism in regulation of insulin secretion from pancreatic beta cells.Minireview: hey U(PS): metabolic and proteolytic homeostasis linked via AMPK and the ubiquitin proteasome system.Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.AMPK as Target for Intervention in Childhood and Adolescent ObesitymTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells.The Role of Nutraceuticals in Pancreatic Cancer Prevention and Therapy: Targeting Cellular Signaling, MicroRNAs, and Epigenome.Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets.AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration.Impact of three oral antidiabetic drugs on markers of β-cell function in patients with type 2 diabetes: a meta-analysis.AMPK inhibition in health and disease.Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseasesCigarette smoke components induce matrix metalloproteinase-1 in aortic endothelial cells through inhibition of mTOR signaling.Possible contribution of taurine to distorted glucagon secretion in intra-islet insulin deficiency: a metabolome analysis using a novel α-cell model of insulin-deficient diabetes.Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null miceMetabolomics Analysis Reveals that AICAR Affects Glycerolipid, Ceramide and Nucleotide Synthesis Pathways in INS-1 Cells.Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscleDifferential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 CellsLoss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic α2A receptor through the mTOR (mammalian target of rapamycin) pathway: implication in new-onset diabetes in renal transplantationActivation of AMPK Stimulates Neurotensin Secretion in Neuroendocrine CellsIncreased fetal insulin concentrations for one week fail to improve insulin secretion or β-cell mass in fetal sheep with chronically reduced glucose supply
P2860
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P2860
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.
@en
type
label
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.
@en
prefLabel
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.
@en
P2093
P2860
P356
P1476
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.
@en
P2093
Catherine E Gleason
Christopher B Newgard
Danhong Lu
Lee A Witters
P2860
P304
10341-10351
P356
10.1074/JBC.M610631200
P407
P577
2007-02-07T00:00:00Z