Distinct roles for LINE-1 and HERV-K retroelements in cell proliferation, differentiation and tumor progression.
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Roles for retrotransposon insertions in human diseaseThe Reverse Transcriptase Encoded by LINE-1 Retrotransposons in the Genesis, Progression, and Therapy of CancerEndogenous retroviruses and the development of cancerGenetic Engineering of T Cells to Target HERV-K, an Ancient Retrovirus on MelanomaAssociation between Long Interspersed Nuclear Element-1 Methylation and Relative Telomere Length in Wilms TumorA reverse transcriptase-dependent mechanism is essential for murine preimplantation developmentTransition of LINE-1 DNA methylation status and altered expression in first and third trimester placentas.The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines.A human endogenous retrovirus-derived gene that can contribute to oncogenesis by activating the ERK pathway and inducing migration and invasionSilencing of LINE-1 retrotransposons contributes to variation in small noncoding RNA expression in human cancer cells.LINE-1 induces hTERT and ensures telomere maintenance in tumour cell lines.Regulatory roles of LINE-1-encoded reverse transcriptase in cancer onset and progression.Human endogenous retroviruses and cancer prevention: evidence and prospectsMutations in retrotransposon AtCOPIA4 compromises resistance to Hyaloperonospora parasitica in Arabidopsis thaliana.Expression of a LINE-1 endonuclease variant in gastric cancer: its association with clinicopathological parameters.Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer.Extensive somatic L1 retrotransposition in colorectal tumors.Human endogenous retroviral K element encodes fusogenic activity in melanoma cells.Enhanced expression of LINE-1-encoded ORF2 protein in early stages of colon and prostate transformationRetrotransposon-encoded reverse transcriptase in the genesis, progression and cellular plasticity of human cancer.HERV-K(HML-2), the Best Preserved Family of HERVs: Endogenization, Expression, and Implications in Health and Disease.Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor.LINEs of evidence: noncanonical DNA replication as an epigenetic determinantIncreased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression.Inhibition of LINE-1 retrotransposon-encoded reverse transcriptase modulates the expression of cell differentiation genes in breast cancer cells.A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines.Pathological and evolutionary implications of retroviruses as mobile genetic elements.HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features.Antitumor effect of combination of the inhibitors of two new oncotargets: proton pumps and reverse transcriptase.Activation of LINE-1 Retrotransposon Increases the Risk of Epithelial-Mesenchymal Transition and Metastasis in Epithelial Cancer.Towards new therapeutic approaches for malignant melanoma.Human endogenous retroviruses and cancer: causality and therapeutic possibilities.The DNA Habitat and its RNA Inhabitants: At the Dawn of RNA Sociology.Down-regulation of human endogenous retrovirus type K (HERV-K) viral env RNA in pancreatic cancer cells decreases cell proliferation and tumor growth.Characterization and comparison of telomere length, telomerase and reverse transcriptase activity and gene expression in human mesenchymal stem cells and cancer cells of various origins.Expression of human endogenous retrovirus K is stimulated by ultraviolet radiation in melanoma.Expression of HERV-K correlates with status of MEK-ERK and p16INK4A-CDK4 pathways in melanoma cells.Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelementsHuman cytomegalovirus (HCMV) induces human endogenous retrovirus (HERV) transcription.Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3.
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Distinct roles for LINE-1 and HERV-K retroelements in cell proliferation, differentiation and tumor progression.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Distinct roles for LINE-1 and ...... tiation and tumor progression.
@en
type
label
Distinct roles for LINE-1 and ...... tiation and tumor progression.
@en
prefLabel
Distinct roles for LINE-1 and ...... tiation and tumor progression.
@en
P2093
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Distinct roles for LINE-1 and ...... ntiation and tumor progression
@en
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Schumann GG
Spadafora C
Tolstonog GV
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P356
10.1038/SJ.ONC.1210214
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P577
2007-01-22T00:00:00Z
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P6179
1046258259