Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.
about
Redox homeostasis in pancreatic β cellsA combination of nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic Goto-Kakizaki ratsMutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretionGlucolipotoxicity of the pancreatic beta cell.Mitochondrial uncoupling and lifespan.Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass.Leucine metabolism in regulation of insulin secretion from pancreatic beta cells.Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.Expression of PPARalpha modifies fatty acid effects on insulin secretion in uncoupling protein-2 knockout mice.Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells.Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?Glucolipotoxicity: fuel excess and beta-cell dysfunction.UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival.High- and low-calcium-dependent mechanisms of mitochondrial calcium signallingMitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3?Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion.Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation.Uncoupling protein UCP2: when mitochondrial activity meets immunity.The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.H₂O₂-Activated Mitochondrial Phospholipase iPLA₂γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein-Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic β-CellsWhen less is more: hormesis against stress and disease.Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity.Overlap of Doxycycline Fluorescence with that of the Redox-Sensitive Intracellular Reporter roGFP.Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.Mitochondrial uncoupling proteins: subtle regulators of cellular redox signaling.
P2860
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P2860
Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Increasing uncoupling protein- ...... on of reactive oxygen species.
@en
type
label
Increasing uncoupling protein- ...... on of reactive oxygen species.
@en
prefLabel
Increasing uncoupling protein- ...... on of reactive oxygen species.
@en
P2093
P1433
P1476
Increasing uncoupling protein- ...... ion of reactive oxygen species
@en
P2093
A Gjinovci
C B Wollheim
F Assimacopoulos-Jeannet
H Perreten
N Davis-Lameloise
N Produit-Zengaffinen
P A Keller
P2888
P356
10.1007/S00125-006-0499-6
P577
2006-11-28T00:00:00Z