An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis. - Wikidata - wikimedia - TriplyDB

An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis.

An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis.

http://www.wikidata.org/entity/Q40208980

about

KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate Synergistic anticancer effects of the 9.2.27PE immunotoxin and ABT-737 in melanoma Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells.Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?p53 suppresses structural chromosome instability after mitotic arrest in human cells.Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells Caspase activity is not required for the mitotic checkpoint or mitotic slippage in human cells.A phase I trial of MK-0731, a kinesin spindle protein (KSP) inhibitor, in patients with solid tumors.Bmk-1 regulates lifespan in Caenorhabditis elegans by activating hsp-16.Antimitotic agents for the treatment of patients with metastatic castrate-resistant prostate cancer.Kinesin spindle protein (KSP) inhibitors in combination with chemotherapeutic agents for cancer therapy.Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells.Eg5 Overexpression Is Predictive of Poor Prognosis in Hepatocellular Carcinoma Patients.Chromosome 20q amplification regulates in vitro response to Kinesin-5 inhibitor.Highly efficient eradication of intracranial glioblastoma using Eg5 siRNA combined with HVJ envelope.Kinesin family member 11 contributes to the progression and prognosis of human breast cancer.The kinesin spindle protein inhibitor filanesib enhances the activity of pomalidomide and dexamethasone in multiple myeloma.Overexpression of Eg5 correlates with high grade astrocytic neoplasm.

P2860

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P2860

An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis.

http://www.wikidata.org/entity/Q40208980

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

@zh-hk

2006年論文

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2006年論文

@zh-tw

2006年论文

@wuu

2006年论文

@zh

2006年论文

@zh-cn

name

An inhibitor of the kinesin sp ...... and de novo protein synthesis.

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type

label

An inhibitor of the kinesin sp ...... and de novo protein synthesis.

@en

prefLabel

An inhibitor of the kinesin sp ...... and de novo protein synthesis.

@en

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P1433

Molecular and Cellular Biology

P1476

An inhibitor of the kinesin sp ...... and de novo protein synthesis.

@en

P2093

Joseph P Davide

http://www.w3.org/2001/XMLSchema#string

Kenneth L Arrington

http://www.w3.org/2001/XMLSchema#string

Laura Sepp-Lorenzino

http://www.w3.org/2001/XMLSchema#string

Mark E Fraley

http://www.w3.org/2001/XMLSchema#string

Robert B Lobell

http://www.w3.org/2001/XMLSchema#string

Ronald E Diehl

http://www.w3.org/2001/XMLSchema#string

Victoria J South

http://www.w3.org/2001/XMLSchema#string

Weikang Tao

http://www.w3.org/2001/XMLSchema#string

P2860

p53 has a direct apoptogenic role at the mitochondria

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

Conformation of the Bax C-terminus regulates subcellular location and cell death

Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle

Movement of Bax from the cytosol to mitochondria during apoptosis

P304

689-698

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scholarly article

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10.1128/MCB.01505-06

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2

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27

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2006-11-13T00:00:00Z

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17101792

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P921

apoptotic process

P932

1800817

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