Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes.
about
Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapseRab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cellsCongenital defects in neutrophil dynamicsRegulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectorsNeisseria gonorrhoeae phagosomes delay fusion with primary granules to enhance bacterial survival inside human neutrophils.Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachmentVesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophilsMST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membraneA neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.DNase I inhibits a late phase of reactive oxygen species production in neutrophils.Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms.A role for Rab27 in neutrophil chemotaxis and lung recruitment.Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophilsMUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils.Genetic heterogeneity in severe congenital neutropenia: how many aberrant pathways can kill a neutrophil?An essential role for Rab27a GTPase in eosinophil exocytosis.A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.Neutropenia and primary immunodeficiency diseases.Pathways for cytokine secretion.Resisting viral infection: the gene by gene approach.The role of Rab27a in the regulation of neutrophil function.Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.Peptoanaerobacter stomatis Primes Human Neutrophils and Induces Granule Exocytosis.Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation.Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodelingCross-talk between IRAK-4 and the NADPH oxidase.Prediction and comparison of Salmonella-human and Salmonella-Arabidopsis interactomesRab GTPases in Immunity and InflammationArmed for destruction: formation, function and trafficking of neutrophil granules.Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis.Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TRExpression and role of a2 vacuolar-ATPase (a2V) in trafficking of human neutrophil granules and exocytosis.
P2860
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P2860
Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Rab27a is a key component of t ...... ilic granules in granulocytes.
@en
type
label
Rab27a is a key component of t ...... ilic granules in granulocytes.
@en
prefLabel
Rab27a is a key component of t ...... ilic granules in granulocytes.
@en
P2093
P2860
P50
P356
P1433
P1476
Rab27a is a key component of t ...... ilic granules in granulocytes.
@en
P2093
Beverly A Ellis
Daniela B Munafó
Jennifer L Johnson
P2860
P304
P356
10.1042/BJ20060950
P407
P577
2007-03-01T00:00:00Z