Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.
about
Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosisLipid metabolic reprogramming in cancer cellsNovel agents for multiple myeloma to overcome resistance in phase III clinical trialsTargeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignanciesLipid raft: A floating island of death or survivalInhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and PraziquantelIn vitro and in vivo evaluation of 2-aminoalkanol and 1,2-alkanediamine derivatives against Strongyloides venezuelensis.In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosineInvolvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cellsIn vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasitesCeramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine.Constitutive localization of DR4 in lipid rafts is mandatory for TRAIL-induced apoptosis in B-cell hematologic malignancies.A Phase 1, Multi-Center, Open-Label, Dose-Escalation Study of 131I-CLR1404 in Subjects with Relapsed or Refractory Advanced Solid Malignancies.Affinity of alkylphosphocholines to biological membrane of prostate cancer: studies in natural and model systemsSynthetic glycosidated phospholipids induce apoptosis through activation of FADD, caspase-8 and the mitochondrial death pathway.Molecular targets for selective killing of TRAIL-resistant leukemic cells.Lipid raft-targeted therapy in multiple myeloma.CD74 interferes with the expression of fas receptor on the surface of lymphoma cellsThe SK3/K(Ca)2.3 potassium channel is a new cellular target for edelfosine.Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions.OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cellsInvolvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria.Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussionSphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy.Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosineSilencing of anti-apoptotic transmembrane protein lifeguard sensitizes solid tumor cell lines MCF-7 and SW872 to perifosine-induced cell death activation.Bone marrow microenvironment and the identification of new targets for myeloma therapy.Genome-wide identification of genetic determinants for the cytotoxicity of perifosine.Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeastHuman cytomegalovirus inhibits apoptosis by proteasome-mediated degradation of Bax at endoplasmic reticulum-mitochondrion contactsPreclinical studies of novel targeted therapies.PI3 kinase/AKT pathway as a therapeutic target in multiple myeloma.From the bench to the bedside: emerging new treatments in multiple myeloma.Importance of the difference in surface pressures of the cell membrane in doxorubicin resistant cells that do not express Pgp and ABCG2.Glycosylphosphatidylinositol-anchored protein deficiency confers resistance to apoptosis in PNH.DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling: insights from FAS, FAS ligand and RASSF1A.Synergistic cytotoxicity of gemcitabine, clofarabine and edelfosine in lymphoma cell lines.Emerging therapies for B-cell non-Hodgkin lymphoma.Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma.Novel therapeutic targets for multiple myeloma.
P2860
Q21202788-B84D55E0-1AE7-4864-A426-7337983A0E5FQ26774859-93E321F3-F6F9-4907-B29E-D309D5D586C6Q26822754-D653D0D8-2B3A-4611-AC0C-C3D2BF379632Q26829652-CF0549CE-8B8F-486F-9C20-A811731CED22Q26998351-D53A4F2E-58CE-4B25-A1A4-ADE931F28F57Q27304398-41F357A8-11EB-44EC-9A13-CCD643A65BA4Q27329055-3C5E91C5-B07C-4005-8321-AA34EFE076CDQ27339703-E2B20779-3DD8-4A20-A0A6-1DA294AEF53EQ28475228-F05046CF-A90C-4B46-9595-94E166B3940BQ28482212-66E1C0E4-9DA6-4D27-8603-E5202752A586Q30523059-B3353887-46BA-4E57-AF1B-F073966F98DBQ30571484-9BEE77D7-7D08-4CFE-A82F-F4EBCCF1B6AFQ33427321-77765C3A-7DF8-4963-AC05-D09260D293CBQ33735663-31FDBC7A-C8FB-443D-A8D2-48C82D6F4452Q33855963-C392CA37-02B9-4300-A4A4-CC13D1875E68Q33891400-9C2F2A6E-3961-4AEE-80FD-73765109A5C5Q34112080-05220CC2-1644-4809-8D64-90F59648AA39Q34409837-32FB5843-8E8E-4726-9566-461211EBABCBQ34540226-2DAEB216-2D56-4BCF-9E75-24EF143F23C4Q34609399-44EF3E1C-EE69-4AA4-9EE6-FD44ABC47C64Q34876742-69396083-70F8-4ED3-9642-265F8C6E70D9Q35064991-1993971E-2D05-4800-9CA8-E86C7D540F6EQ35480734-B765166F-A5E3-428D-B77A-A7A55FF22031Q35621265-39A47FE3-4F85-41A4-A7BE-DAF26D42F929Q35987417-9CCD5E10-4416-4E80-AE31-2C06333FA2B6Q36135521-7E517EE6-6F9B-480C-BC06-876D0F2775B0Q36162703-661A808E-4FFE-4AC2-900C-9B4BEDA84B1CQ36475047-8B023C27-0AB0-4C92-9658-2FB47345D3F5Q36708592-1EF8AE0B-E521-4882-8978-9313B86DBA88Q36827271-96618C15-AB0A-4FC0-AAE1-298178E8BB65Q36998210-1F65F412-44D1-4AEF-A8FE-C15F00BFD93FQ37016007-882D76C6-0185-4B74-9965-6D4BE4343200Q37028598-0A514F5D-B419-471D-A861-06EFA2FAEC6AQ37054441-95E4C915-4666-4926-A565-0EE83E2E613AQ37067277-277ACFE3-074F-41B3-8054-7E4E5E6425A6Q37273862-98CA45EF-134D-4A60-9578-0E046A28EA6CQ37555298-7DD8EAB0-FF22-4970-92F5-68BA17810DDFQ37598947-F5F46198-1505-4282-8A68-CBB75510AF17Q37625678-9DE34B25-D1EE-4EB3-9E64-844AFA2B274BQ37707383-38A3B542-DB7E-4486-BB78-BF54119AE6A7
P2860
Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Edelfosine and perifosine indu ...... ng molecules into lipid rafts.
@en
type
label
Edelfosine and perifosine indu ...... ng molecules into lipid rafts.
@en
prefLabel
Edelfosine and perifosine indu ...... ng molecules into lipid rafts.
@en
P1433
P1476
Edelfosine and perifosine indu ...... ing molecules into lipid rafts
@en
P2093
Faustino Mollinedo
P304
P356
10.1182/BLOOD-2006-04-016824
P407
P577
2006-09-26T00:00:00Z