Thoracic aortic disease in tuberous sclerosis complex: molecular pathogenesis and potential therapies in Tsc2+/- mice.
about
Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves.Loss-of-Function Mutations in YY1AP1 Lead to Grange Syndrome and a Fibromuscular Dysplasia-Like Vascular Disease.Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cellsThe genetic basis of aortic aneurysmSmooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycinSpatiotemporal expression of matrix metalloproteinases (MMPs) is regulated by the Ca2+-signal transducer S100A4 in the pathogenesis of thoracic aortic aneurysm.Lessons on the pathogenesis of aneurysm from heritable conditionsSmooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β.Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.Proteomics in aortic aneurysm--what have we learnt so far?Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms.Inhibition of the mTOR pathway in abdominal aortic aneurysm: implications of smooth muscle cell contractile phenotype, inflammation, and aneurysm expansion.Combined treatment with bexarotene and rosuvastatin reduces angiotensin-II-induced abdominal aortic aneurysm in apoE(-/-) mice and angiogenesis.Rapamycin inhibits CaCl2-induced thoracic aortic aneurysm formation in rats through mTOR-mediated suppression of proinflammatory mediators.Targeted deletion of Tsc1 causes fatal cardiomyocyte hyperplasia independently of afterload.Conservation of structural and functional elements of TSC1 and TSC2: a bioinformatic comparison across animal models.
P2860
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P2860
Thoracic aortic disease in tuberous sclerosis complex: molecular pathogenesis and potential therapies in Tsc2+/- mice.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Thoracic aortic disease in tub ...... ial therapies in Tsc2+/- mice.
@en
type
label
Thoracic aortic disease in tub ...... ial therapies in Tsc2+/- mice.
@en
prefLabel
Thoracic aortic disease in tub ...... ial therapies in Tsc2+/- mice.
@en
P2093
P2860
P356
P1476
Thoracic aortic disease in tub ...... ial therapies in Tsc2+/- mice.
@en
P2093
Anthony Estrera
Callie S Kwartler
Dianna M Milewicz
Dong-chuan Guo
Hazim Safi
Jiumei Cao
Limin Gong
Michael J Gambello
Shao-Qing Kuang
Ulrike Mietzsch
P2860
P304
P356
10.1093/HMG/DDQ066
P577
2010-02-16T00:00:00Z