about
Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and CognitionA critical role for IGF-II in memory consolidation and enhancement.MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formationImplanted BDNF-producing fibroblasts prevent neurotoxin-induced serotonergic denervation in the rat striatum.Disrupting the memory of places induced by drugs of abuse weakens motivational withdrawal in a context-dependent mannerInsulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic miceSildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease.Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease.Phosphodiesterase inhibition in cognitive decline.Epigenetic drugs in Alzheimer's disease.Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels.Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.Current animal models of Alzheimer's disease: challenges in translational research.Amyloid beta mediates memory formation.Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF.Facilitation by 8-OH-DPAT of passive avoidance performance in rats after inactivation of 5-HT(1A) receptors.BDNF mediates the neuroprotective effect of PACAP-38 on rat cortical neurons.Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD.Reduced basal and phencyclidine-induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone.Increased CRE-binding activity and tryptophan hydroxylase mRNA expression induced by 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rat frontal cortex but not in the hippocampus.Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.The aberrant splicing of BAF45d links splicing regulation and transcription in glioblastoma.Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease.Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease.A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.Differential regulation by methylenedioxymethamphetamine of 5-hydroxytryptamine1A receptor density and mRNA expression in rat hippocampus, frontal cortex, and brainstem: the role of corticosteroids.Synthesis and evaluation of (13)N-labelled azo compounds for β-amyloid imaging in mice.Immunomodulatory Properties of Carvone Inhalation and Its Effects on Contextual Fear Memory in Mice.Chronic Mild Stress Assay Leading to Early Onset and Propagation of Alzheimer's Disease Phenotype in Mouse Models.Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice.Long-term phenylbutyrate administration prevents memory deficits in Tg2576 mice by decreasing Abeta.Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.Impact of Neurodegenerative Diseases on Drug Binding to Brain Tissues: From Animal Models to Human Samples.Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse ModelsEffect of p-Chloroamphetamine on 5-HT1A and 5-HT7 Serotonin Receptor Expression in Rat Brain
P50
Q26771954-EB72BE8E-5745-4ADB-90E0-5B867BFEBB7BQ28304084-C63B3147-C222-4934-A991-3439EB05FF0AQ28572604-C6C41D20-78E7-4518-9E86-2FB2864FD5F8Q30857373-F68AF88C-42BB-419A-B965-4F9DD8E6DF6FQ33982210-0F903E0A-6FE2-41A2-AFDE-38F405CC632BQ34880331-0E3BC849-386B-4EEF-95A6-2FD71E970105Q35635988-2BD53626-9CD8-4B67-9C25-9CB3F11666A9Q36142843-A5A19613-F101-4405-A3FE-4BE8078E69F8Q37968693-EBEFC1D8-DC23-4E1F-85AF-4F3365CAE038Q38240108-89EDF845-E9EF-43FC-A0F5-8F57F96B1B89Q38273179-BA6BA207-8C04-4DF1-8872-CC5C228E8420Q38747622-DBF5D346-02B4-4056-999E-2F7BD5197E43Q40238471-1654EA2D-803A-4366-9764-5B381D75EC86Q41762801-7DEAB6B2-C901-4D2C-AD14-B50E81FD97FDQ42921189-9FEC587B-F2CE-45CC-B8E6-5D17820D8F1EQ43155401-AAF47A71-2FF9-4BD7-9C5A-541BD6421AD8Q43181744-B2FEC185-AE3B-4361-9727-C4833226FC33Q43261752-B6C4C344-5CD9-4512-B14D-9E4DFFD637DDQ43575941-FAAA56C6-C877-469B-B90E-94B829C5AD67Q43648215-34B611F3-5EA9-49DE-BA5F-7BC503D7E25CQ44025423-5FD9464E-DBCC-4C86-9892-9D4EA733BB0EQ44292631-A6E71AAB-4C19-466F-9EF8-95E3FF0A6B3AQ44974818-FF4F8100-43A8-4A02-BA25-14F193865866Q46162286-737619BE-5AEA-4F2D-B95D-213FC8A774C2Q47837824-E5AB322F-9701-49DC-A604-35907BD438E3Q48145316-8A907965-3CD7-4C3C-86A4-7D616F7472B1Q48168481-A6EC6BDC-0734-4443-91A4-31EB03CEF500Q48419390-CAA210E9-3362-42D4-9DEC-2C772D28BF26Q48557521-EB3E2A32-C337-4F11-B6B1-D9DF0B0542C7Q48793536-D12F2806-F979-499C-A200-C360A84B431DQ48823625-B7D3096F-8AF4-4C66-97D9-1CAE67C7C96BQ49200005-7E8DC4B6-48EC-4C00-BABE-43D46381E248Q50718514-C3BCFF74-ABBE-4D51-99FE-6382EBFD69C9Q50985006-A65C8E7C-232B-42C2-BE37-F8234C5D861EQ51006843-80910DC9-6F94-4ECE-9E9D-0EFF193F49ECQ51891263-8811B6B1-AD2F-49E6-8DD2-4A9FA9FF695EQ52650948-4D0D8767-C241-4376-95F4-D9793E1FB83EQ53397308-6C79C2DB-8AE5-44AB-BDB2-2A68366C6545Q61700148-B27B12E2-D996-4A03-8D2E-4AE178A2B416Q63323774-B6511B3C-F1AB-45EC-B34D-D4C9C9B0426B
P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Ana García-Osta
@ast
Ana García-Osta
@en
Ana García-Osta
@es
Ana García-Osta
@nl
type
label
Ana García-Osta
@ast
Ana García-Osta
@en
Ana García-Osta
@es
Ana García-Osta
@nl
altLabel
A Garcia-Osta
@en
prefLabel
Ana García-Osta
@ast
Ana García-Osta
@en
Ana García-Osta
@es
Ana García-Osta
@nl
P106
P1153
6508009541
P21
P31
P496
0000-0001-6326-9064